Q5R7G8
Gene name |
MINDY1 (FAM63A) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase MINDY-1 |
Names |
Deubiquitinating enzyme MINDY-1, Protein FAM63A |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174611 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R7G8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R7G8-F1 | Predicted | AlphaFoldDB |
No variants for Q5R7G8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R7G8 | |||||
No associated diseases with Q5R7G8
1 regional properties for Q5R7G8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MINDY deubiquitinase domain | 143 - 266 | IPR033979 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| K48-linked polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. |
| Lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHHQPEDPA | PGKAGTVEAD | IPKNHEVLAG | PYEHPQDTDA | RDADGEAGER | EPADQALLPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QCGDNLESPL | PEAGSAPPGP | TLGTLPEVET | IKACSMPQEL | PQSPRTRQPE | PDFYCVKWIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WKGERTPIIT | QSTNGPCPLL | AIMNILFLQW | KVKLPPQKEV | ITSDELMAHL | GNCLLSIKPQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKSEGLQLNF | QQNVDDAMTV | LPKLATGLDV | NARFTGVSDF | EYTPECSVFD | LLGIPLYHGW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVDPQSPEAV | RAVGKLSYNQ | LVERIITCKH | SSDTNLVTKG | LVAEQFLETT | AAQLTYHGLC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELTAAAKEGE | LSVFFRNNHF | STMTKHKSHL | YLLVTDQGFL | QEEQIVWESL | HNVDGDSCFC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DSDFHLSHSL | GKGPGAEGGS | GSPEKQLQVD | QDYLIALSLQ | QQQPRGTLGL | TDLELAQQLQ |
| 430 | 440 | 450 | 460 | ||
| QEEYQQQQAA | QPVWMRTRAL | SPQGRGATSG | RPAGERRQRP | KHESDCILL |