Q5R754

PR
Gene name
CDKL2
Protein name
Cyclin-dependent kinase-like 2
Names
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173402
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

285-482 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-166 (Activation loop from InterPro)

Target domain

4-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5R754

Entry ID Method Resolution Chain Position Source
AF-Q5R754-F1 Predicted AlphaFoldDB

No variants for Q5R754

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R754

No associated diseases with Q5R754

5 regional properties for Q5R754

Type Name Position InterPro Accession
domain F-box domain 29 - 76 IPR001810
domain Cyclin, C-terminal domain 408 - 531 IPR004367
domain Cyclin, N-terminal 288 - 405 IPR006671
domain Cyclin-like domain 315 - 399 IPR013763-1
domain Cyclin-like domain 416 - 494 IPR013763-2

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH
70 80 90 100 110 120
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH
130 140 150 160 170 180
NIIHRDIKPE NILVSKSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG
190 200 210 220 230 240
KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL
250 260 270 280 290 300
PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350 360
QLKVQKDARN VSLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNADPKIKD CKLFKIKGSK
370 380 390 400 410 420
IDGEKAEKGS RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS
430 440 450 460 470 480
AVAPGINSGM GTATIPIQGH RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD
490
DSGADLPQME HQH