Q5R6T1
Gene name |
PDIA6 |
Protein name |
Protein disulfide-isomerase A6 |
Names |
|
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173470 |
EC number |
5.3.4.1: Transposing S-S bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R6T1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R6T1-F1 | Predicted | AlphaFoldDB |
No variants for Q5R6T1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R6T1 | |||||
No associated diseases with Q5R6T1
6 regional properties for Q5R6T1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein disulfide-isomerase, thioredoxin-like domain | 30 - 125 | IPR005788-1 |
| domain | Protein disulfide-isomerase, thioredoxin-like domain | 165 - 263 | IPR005788-2 |
| domain | Thioredoxin domain | 4 - 126 | IPR013766-1 |
| domain | Thioredoxin domain | 124 - 287 | IPR013766-2 |
| conserved_site | Thioredoxin, conserved site | 47 - 65 | IPR017937-1 |
| conserved_site | Thioredoxin, conserved site | 182 - 200 | IPR017937-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.4.1 | Transposing S-S bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein disulfide isomerase activity | Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
| platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLVLGLVS | CAFFLEVNGL | YSSSDDVIEL | TPSNFNREVI | QSDSLWLVEF | YAPWCGHCQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTPEWKKAAT | ALKDVVKVGA | VDADKHHSLG | GQYGVQGFPT | IKIFGSNKNR | PEDYQGGRTG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAIVDAALSA | LRQLVKDRLG | GQSGGYSSGK | QGRSDSSSKK | DVIELTDDSF | DKNVLDSEDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WMVEFYAPWC | GHCKNLEPEW | AAAASEVKEQ | TKGKVKLAAV | DATVNQVLAS | RYGIRGFPTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KIFQKGESPV | DYDGGRTRSD | IVSRALDLFS | DNAPPPELLE | IISEDIAKRT | CEEHQLCVVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLPHILDTGA | AGRNSYLEVL | LKLADKYKKK | MWGWLWTEAG | AQSELETALG | IGGFGYPAMA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AINARKMKFA | LLKGSFSEQG | INEFLRELSF | GRGSTAPVGG | GAFPTIVERE | PWDGRDGELP |
| 430 | |||||
| VEDDIDLSDV | ELDDLGKDEL |