Q5R6I2
Gene name |
MYOZ2 |
Protein name |
Myozenin-2 |
Names |
Calsarcin-1 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173530 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R6I2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R6I2-F1 | Predicted | AlphaFoldDB |
No variants for Q5R6I2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R6I2 | |||||
No associated diseases with Q5R6I2
No regional properties for Q5R6I2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5R6I2 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| telethonin binding | Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of calcineurin-NFAT signaling cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| sarcomere organization | The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| skeletal muscle fiber adaptation | Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. |
| skeletal muscle tissue development | The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSHNTMVKQ | RKQQATAIMK | EVHGNDVDGM | DLGKKVSIPR | DIMLEELSHL | SNRGARLFKM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQRRSDKYTF | ENFQYQSRAQ | INHSIAMQNG | KVDGSNLEGG | SQQAPLTPPN | TPDPRSPPNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNIAPGYSGP | LKEIPPEKFN | TTAVPKYYQS | PWEQAISNDP | ELLEALYPKL | FKPEGKAELP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DYRSFNRVAT | PFGGFEKASR | MVKFKVPDFE | LLLLTDPRFM | SFVNPLSGRR | SFNRTPKGWI |
| 250 | 260 | ||||
| SENIPIVITT | EPTDDTTVPE | SEDL |