Q5R6G8

PR
Gene name
IST1
Protein name
IST1 homolog
Names
Charged multivesicular body protein 8, CHMP8
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173540
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

154-364 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R6G8

Entry ID Method Resolution Chain Position Source
AF-Q5R6G8-F1 Predicted AlphaFoldDB

No variants for Q5R6G8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R6G8

No associated diseases with Q5R6G8

No regional properties for Q5R6G8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5R6G8

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Midbody
  • Nucleus envelope
  • Localizes to centrosome and midbody of dividing cells
  • Colocalized with SPART to the ends of Flemming bodies during cytokinesis
  • Localizes to the reforming nuclear envelope on chromatin disks during late anaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII
70 80 90 100 110 120
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV
130 140 150 160 170 180
ADQLCAKYSK GYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD
190 200 210 220 230 240
SVVMAEAPPG VETDLIDVGF TDDVKKGGPG RGGGGGFTAP VGGPEGTVPM PMPMPMPSAN
250 260 270 280 290 300
TPFSYPLPKG PSDFNGLPMG TYQAFPIIHP PQIPATPPSY ESVDDINADK NISSAQIVGP
310 320 330 340 350 360
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF DDLSRRFEEL
KKKT