Q5R6B2

PR
Gene name
GABRA1
Protein name
Gamma-aminobutyric acid receptor subunit alpha-1
Names
GABA(A) receptor subunit alpha-1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

321-437 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R6B2

Entry ID Method Resolution Chain Position Source
AF-Q5R6B2-F1 Predicted AlphaFoldDB

No variants for Q5R6B2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R6B2

No associated diseases with Q5R6B2

5 regional properties for Q5R6B2

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 257 - 341 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 43 - 250 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 166 - 180 IPR018000
domain Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain 252 - 439 IPR047024
domain Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain 56 - 249 IPR047079

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
chloride channel complex An ion channel complex through which chloride ions pass.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
GABA-A receptor complex A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name Definition
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
GABA-A receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.

2 GO annotations of biological process

Name Definition
gamma-aminobutyric acid signaling pathway The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.
inhibitory synapse assembly The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKSPGLSDC LWAWILLLST LTGRSYGQPS LQDELKDNTT VFTRILDRLL DGYDNRLRPG
70 80 90 100 110 120
LGERVTEVKT DIFVTSFGPV SDHDMEYTID VFFRQSWKDE RLKFKGPMTV LRLNNLMASK
130 140 150 160 170 180
IWTPDTFFHN GKKSVAHNMT MPNKLLRITE DGTLLYTMRL TVRAECPMHL EDFPMDAHAC
190 200 210 220 230 240
PLKFGSYAYT RAEVVYEWTR EPARSVVVAE DGSRLNQYDL LGQTVDSGIV QSSTGEYVVM
250 260 270 280 290 300
TTHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA
310 320 330 340 350 360
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GYAWDGKSVV PEKPKKVKDP
370 380 390 400 410 420
LIKKNNTYAP TATSYTPNLA GGDPGLATIA KSATIEPKEV KPETKPPEPK KTFNSVSKID
430 440 450
RLSRIAFPLL FGIFNLIYWA TYLNREPQLK APTPHQ