Q5R5V5
Gene name |
ATP6V1B2 |
Protein name |
V-type proton ATPase subunit B, brain isoform |
Names |
V-ATPase subunit B 2, Vacuolar proton pump subunit B 2 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173673 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R5V5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R5V5-F1 | Predicted | AlphaFoldDB |
No variants for Q5R5V5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R5V5 | |||||
No associated diseases with Q5R5V5
3 regional properties for Q5R5V5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain | 173 - 399 | IPR000194 |
| domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain | 50 - 116 | IPR004100 |
| active_site | ATPase, alpha/beta subunit, nucleotide-binding domain, active site | 390 - 399 | IPR020003 |
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
| vacuolar proton-transporting V-type ATPase, V1 domain | The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP metabolic process | The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRAMRGIV | NGAAPELPVP | TGGPTVGARE | QALAVSRNYL | SQPRLTYKTV | SGVNGPLVIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DHVKFPRYAE | IVHLTLPDGT | KRSGQVLEVS | GSKAVVQVFE | GTSGIDAKKT | SCEFTGDILR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPVSEDMLGR | VFNGSGKPID | RGPVVLAEDF | LDIMGQPINP | QCRIYPEEMI | QTGISAIDGM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSIARGQKIP | IFSAAGLPHN | EIAAQICRQA | GLVKKSKDVV | DYSEENFAIV | FAAMGVNMET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ARFFKSDFEE | NGSMDNVCLF | LNLANDPTIE | RIITPRLALT | TAEFLAYQCE | KHVLVILTDM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSYAEALREV | SAAREEVPGR | RGFPGYMYTD | LATIYERAGR | VEGRNGSITQ | IPILTMPNDD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITHPIPDLTG | YITEGQIYVD | RQLHNRQIYP | PINVLPSLSR | LMKSAIGEGM | TRKDHADVSN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLYACYAIGK | DVQAMKAVVG | EEALTSDDLL | YLEFLQKFER | NFIAQGPYEN | RTVFETLDIG |
| 490 | 500 | 510 | |||
| WQLLRIFPKE | MLKRIPQSTL | SEFYPRDSAK | H |