Q5R5V2

PR
Gene name
LAMP5
Protein name
Lysosome-associated membrane glycoprotein 5
Names
Brain and dendritic cell-associated LAMP, Brain-associated LAMP-like protein, BAD-LAMP, Lysosome-associated membrane protein 5, LAMP-5
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173676
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R5V2

Entry ID Method Resolution Chain Position Source
AF-Q5R5V2-F1 Predicted AlphaFoldDB

No variants for Q5R5V2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R5V2

No associated diseases with Q5R5V2

No regional properties for Q5R5V2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5R5V2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane ; Single-pass type I membrane protein
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, dendrite
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein
  • Cell projection, growth cone membrane ; Single-pass type I membrane protein
  • Early endosome membrane ; Single-pass type I membrane protein
  • Recycling endosome
  • Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein
  • Endosome membrane ; Single-pass type I membrane protein
  • Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity)
  • Colocalizes with UNC93B1 in large endosomal intracellular vesicles (By similarity)
  • Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (By similarity)
  • Associates with cortical membranes (By similarity)
  • Localizes mostly in cytoplasmic vesicles of neuronal cell body
  • Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
dendrite membrane The portion of the plasma membrane surrounding a dendrite.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
endosome membrane The lipid bilayer surrounding an endosome.
growth cone membrane The portion of the plasma membrane surrounding a growth cone.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLQGRAVPS VDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA
70 80 90 100 110 120
EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVGRCGH SESELQVFWV DRAYALKMLF
130 140 150 160 170 180
VKESHNMSKG PEETWRLSKV QFVYDSSEKT HFKDAVSAGK HTANSHHLSA LVTPAGKSYE
190 200 210 220 230 240
CQAQQTISLA SSDPQKTVTM ILSAVHIQPF DIISDFVFSE EHKCAVDERE QLEETLPLIL
250 260
GLILGLVIVV TLAIYHVHPQ K