Q5R5E5

PR
Gene name
HARS2 (HARSL)
Protein name
Histidine--tRNA ligase, mitochondrial
Names
Histidine--tRNA ligase-like, Histidyl-tRNA synthetase, HisRS
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173789
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R5E5

Entry ID Method Resolution Chain Position Source
AF-Q5R5E5-F1 Predicted AlphaFoldDB

No variants for Q5R5E5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R5E5

No associated diseases with Q5R5E5

4 regional properties for Q5R5E5

Type Name Position InterPro Accession
domain Anticodon-binding 411 - 502 IPR004154
domain Aminoacyl-tRNA synthetase, class II 62 - 417 IPR006195
domain Histidyl-anticodon-binding 409 - 500 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 62 - 395 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
identical protein binding Binding to an identical protein or proteins.

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHLLGLLPRR AWASLLSQLL RPPWASCTGA VRCQSQVAEA VLTSQLKAHQ EKPNFIIKTP
70 80 90 100 110 120
KGTRDLSPQH MVVREKILDL VISCFKRHGA KGMDTPAFEL KETLTEKYGE DSGLMYDLKD
130 140 150 160 170 180
QGGELLSLRY DLTVPFARYL AMNKVKKMKR YHVGKVWRRE SPTIVQGRYR EFCQCDFDIA
190 200 210 220 230 240
GQFDPMIPDA ECLKIMCEIL SGLQLGDFLI KVNDRRIVDG MFAVCGVPES KFRAICSSID
250 260 270 280 290 300
KLDKMAWKDV RHEMVVKKGL APEVADRIGD YVQCHGGVSL VEQMFQDPRL SQNKQALEGL
310 320 330 340 350 360
GDLKLLFEYL TLFGIADKIS FDLSLARGLD YYTGVIYEAV LLQTPTQAGE EPLNVGSVAA
370 380 390 400 410 420
GGRYDGLVGM FDPKGHKVPC VGLSIGVERI FYIVEQRMKT KGEKVRTTET QVFVATPQKN
430 440 450 460 470 480
FLQERLKLIA ELWNSGIKAE MLYKNNPKLL TQLHYCESTG IPLVVIIGEQ ELKEGVIKIR
490 500
SVASREEVAI KRENLVAEIQ KRLSES