Q5R504

PR
Gene name
FAM162A (E2IG5)
Protein name
Protein FAM162A
Names
E2-induced gene 5 protein homolog
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173874
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

99-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R504

Entry ID Method Resolution Chain Position Source
AF-Q5R504-F1 Predicted AlphaFoldDB

No variants for Q5R504

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R504

No associated diseases with Q5R504

10 regional properties for Q5R504

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 319 - 332 IPR000943-1
domain RNA polymerase sigma-70 343 - 351 IPR000943-2
domain RNA polymerase sigma-70 467 - 479 IPR000943-3
domain RNA polymerase sigma-70 488 - 514 IPR000943-4
domain RNA polymerase sigma-70 region 3 374 - 449 IPR007624
domain RNA polymerase sigma-70 region 2 295 - 364 IPR007627
domain RNA polymerase sigma-70 region 4 463 - 516 IPR007630
domain RNA polymerase sigma-70 region 1.2 226 - 259 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 291 - 527 IPR012760
domain RNA polymerase sigma-70 like domain 291 - 516 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of release of cytochrome c from mitochondria Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSLSGLRLA AGSCFRLCER DVFSSLRLTR SSDLKRINGF CTKPQESPRA PSRTYNRVPL
70 80 90 100 110 120
HKPTEWQKKI LVWSGRFKKE DEIPETVSLE MLDTAKNKMR VKISYLMIAL TVVGCICMVI
130 140 150
EGKKAAQRHE SLTSLNLEKK ARLREEAAMK AKTE