Q5R4T8

PR
Gene name
DCAF13 (WDSOF1)
Protein name
DDB1- and CUL4-associated factor 13
Names
WD repeat and SOF domain-containing protein 1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173913
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

376-445 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R4T8

Entry ID Method Resolution Chain Position Source
AF-Q5R4T8-F1 Predicted AlphaFoldDB

No variants for Q5R4T8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R4T8

No associated diseases with Q5R4T8

6 regional properties for Q5R4T8

Type Name Position InterPro Accession
repeat WD40 repeat 55 - 137 IPR001680-1
repeat WD40 repeat 185 - 225 IPR001680-2
repeat WD40 repeat 271 - 362 IPR001680-3
domain Sof1-like protein 354 - 440 IPR007287
domain Translation initiation factor, beta propellor-like domain 200 - 307 IPR013979
conserved_site WD40 repeat, conserved site 82 - 96 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVKMLSRNP DNYVRETKLD LQRVPRNYDP TLHPFEVPRE YVRALNATKL ERVFAKPFLA
70 80 90 100 110 120
SLDGHRDGVN CLAKHPKNLA TVLSGACDGE VRIWNLTQRN CIRTIQAHEG FVRGICTRFC
130 140 150 160 170 180
GTSFFTVGDD KTVKQWKMDG PGYGDEEEPL HTILGKTVYT GIDHHWKEAV FATCGQQVDI
190 200 210 220 230 240
WDEQRTNPVC SMTWGFDSIS SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR
250 260 270 280 290 300
TNTICWNPME AFIFTAANED YNLYTFDMSA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350 360
SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR LWKANASEKL
370 380 390 400 410 420
GVLTSREKAA KDYNQKLKEK FQHYPHIKRI ARHRHLPKSI YSQIQEQRIM KEARRRKEVN
430 440
RIKHSKPGSV PIVSEKKKHV VAVVK