Q5R4R2
Gene name |
HARS1 (HARS) |
Protein name |
Histidine--tRNA ligase, cytoplasmic |
Names |
Histidyl-tRNA synthetase, HisRS |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100173931 |
EC number |
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R4R2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R4R2-F1 | Predicted | AlphaFoldDB |
No variants for Q5R4R2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R4R2 | |||||
No associated diseases with Q5R4R2
5 regional properties for Q5R4R2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | WHEP-TRS domain | 3 - 60 | IPR000738 |
| domain | Anticodon-binding | 410 - 500 | IPR004154 |
| domain | Aminoacyl-tRNA synthetase, class II | 37 - 393 | IPR006195 |
| domain | Histidyl-anticodon-binding | 408 - 499 | IPR033656 |
| domain | Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain | 61 - 394 | IPR041715 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.21 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| histidine-tRNA ligase activity | Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| histidyl-tRNA aminoacylation | The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAERAALEEL | VKLQGERVRG | LKQQKASAEL | IEEEVAKLLK | LKAQLGPDES | KQKFVLKTPK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTRDYSPRQM | AVREKVFDVI | IRCFKRHGAE | VIDTPVFELK | ETLMGKYGED | SKLIYDLKDQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GGELLSLRYD | LTVPFARYLA | MNKLTNIKRY | HIAKVYRRDN | PAMTRGRYRE | FYQCDFDIAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NFDPMIPDAE | CLKIMCEILS | SLQIGDFLVK | VNDRRILDGM | FAICGVSDSK | FRTICSSVDK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDKVSWEEVK | NEMVGEKGLA | PEVADRIGDY | VQQHGGVSLV | EQLLQDPKLS | QSKQALEGLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLKLLFEYLT | LFGIDDKISF | DLSLARGLDY | YTGVIYEAVL | LQTPAQAGEE | PLGVGSVAAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GRYDGLVGMF | DPKGRKVPCV | GLSIGVERIF | SIVEQRLEAL | EEKVRTTETQ | VLVASAQKKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEERLKLVSE | LWDAGIKAEL | LYKKNPKLLN | QLQYCEEAGI | PLVAIIGEQE | LEDGVIKLRS |
| 490 | 500 | ||||
| VTSREEVDVR | REDLVEEIKR | RTGQPLCIC |