Q5R4Q7

PR
Gene name
LZTR1
Protein name
Leucine-zipper-like transcriptional regulator 1
Names
LZTR-1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100173934
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

459-529 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R4Q7

Entry ID Method Resolution Chain Position Source
AF-Q5R4Q7-F1 Predicted AlphaFoldDB

No variants for Q5R4Q7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R4Q7

No associated diseases with Q5R4Q7

2 regional properties for Q5R4Q7

Type Name Position InterPro Accession
domain Zinc finger, RING-type 285 - 324 IPR001841
domain LOG2-like, modified RING finger, C3HC5-type 283 - 324 IPR045195

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system
  • Recycling endosome
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

1 GO annotations of molecular function

Name Definition
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
negative regulation of Ras protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGPGSTGGQ IGAGALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC
70 80 90 100 110 120
DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH
130 140 150 160 170 180
HSAVVYGSSM FVFGGYAGDI YSNSNLKNKN DLFEYKFATG QWTEWKIEGR LPVARSAHGA
190 200 210 220 230 240
TVYSDKLWIF AGYDGNARLN DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVRRDKM
250 260 270 280 290 300
FVFSGQSGAK ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG
310 320 330 340 350 360
GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL TSEERGGFKK
370 380 390 400 410 420
SRDVFGLDFG TTSAKQPAQP ASELPSGRLF HAAAVISDAM YIFGGTVDNN IRSGEMYRFQ
430 440 450 460 470 480
FSCYPKCTLH EDYGRLWESR QFCDVEFVLG EKEECVQGHV AIVTARSRWL RRKITQARER
490 500 510 520 530 540
LAQKLEQEAA PVPREAPGVA AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH
550 560 570 580 590 600
VEDVLLIMDV YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN
610 620 630 640 650 660
FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP SDQPVDIGTS LIQDMKAYLE
670 680 690 700 710 720
GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM PEDGQVNISI GEMVPSRQAF
730 740 750 760 770 780
ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG FYNNRLQAYC KQNLEMNATV QNVLQILEAA
790 800 810 820 830
DKTQALDMKR HCLHIIVHQF TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI