Q5R4J5
Gene name |
SYT1 |
Protein name |
Synaptotagmin-1 |
Names |
Synaptotagmin I, SytI |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100189845 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R4J5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R4J5-F1 | Predicted | AlphaFoldDB |
No variants for Q5R4J5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R4J5 | |||||
No associated diseases with Q5R4J5
6 regional properties for Q5R4J5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 139 - 260 | IPR000008-1 |
| domain | C2 domain | 270 - 403 | IPR000008-2 |
| domain | Synaptotagmin | 274 - 289 | IPR001565-1 |
| domain | Synaptotagmin | 289 - 302 | IPR001565-2 |
| domain | Synaptotagmin | 346 - 361 | IPR001565-3 |
| domain | Synaptotagmin | 366 - 376 | IPR001565-4 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| chromaffin granule membrane | The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| neurotransmitter secretion | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. |
| positive regulation of calcium ion-dependent exocytosis of neurotransmitter | Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSESHHEAL | AAPPVTTVAT | VLPSNATEPA | SPGEGKEDAF | SKLKEKFMNE | LHKIPLPPWA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIAIAIVAVL | LVLTCCFCIC | KKCLFKKKNK | KKGKEKGGKN | AINMKDVKDL | GKTMKDQDDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AETGLTDGEE | KEEPKEEEKL | GKLQYSLDYD | FQNNQLLVGI | IQAAELPALD | MGGTSDPYVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFLLPDKKKK | FETKVHRKTL | NPVFNEQFTF | KVPYSELGGK | TLVMAVYDFD | RFSKHDIIGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKVPMNTVDF | GHVTEEWRDL | QSAEKEEQEK | LGDICFSLRY | VPTAGKLTVV | ILEAKNLKKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DVGGLSDPYV | KIHLMQNGKR | LKKKETTIKK | NTLNPYYNES | FSFEVPFEQI | QKVQVVVTVL |
| 370 | 380 | 390 | 400 | 410 | |
| DYDKIGKNDA | IGKVFVGYNS | TGAELRHWSD | MLANPRRPIA | QWHTLQVEEE | VDAMLAVKK |