Q5R4J1

PR
Gene name
WARS1 (WARS)
Protein name
Tryptophan--tRNA ligase, cytoplasmic
Names
Tryptophanyl-tRNA synthetase, TrpRS
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
EC number
6.1.1.2: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R4J1

Entry ID Method Resolution Chain Position Source
AF-Q5R4J1-F1 Predicted AlphaFoldDB

No variants for Q5R4J1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R4J1

No associated diseases with Q5R4J1

2 regional properties for Q5R4J1

Type Name Position InterPro Accession
domain WHEP-TRS domain 9 - 69 IPR000738
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 165 - 175 IPR001412

Functions

Description
EC Number 6.1.1.2 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a kinase.
protein domain specific binding Binding to a specific domain of a protein.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).

7 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of protein ADP-ribosylation Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPNSEPCVSP LELFNSIATQ GELVRSLKAG NASKDEIDSA VKMLLSLKMS YKAAMGEDYK
70 80 90 100 110 120
ANCPPGNPAP TSNHGPDATE AEEDFVDPWT VQTSSAKGID YDKLIVRFGS SKIDKELINR
130 140 150 160 170 180
IERATGQRPH RFLRRGIFFS HRDMNQVLDA YENKKPFYLY TGRGPSSEAM HVGHLIPFIF
190 200 210 220 230 240
TKWLQDVFNV PLVIQMTDDE KYLWKDLTLD QAYSYAVENA KDIIACGFDI NKTFIFSDLD
250 260 270 280 290 300
YMGMSSGFYK NVVKIQKHVT FNQVKGIFGF TDSDCIGKIS FPAIQAAPSF SNSFPQIFRD
310 320 330 340 350 360
RTDIQCLIPC AIDQDPYFRM TRDVAPRIGY PKPALLHSTF FPALQGAQTK MSASDPNSSI
370 380 390 400 410 420
FLTDTAKQIK TKVNKHAFSG GRDTIEEHRQ FGGNCDVDVS FMYLTFFLED DDKLEQIRKD
430 440 450 460 470
YTSGAMLTGE LKKALIEVLQ PLIAEHQARR KEVTDEIVKE FMTPRKLSFD FQ