Q5R488

PR
Gene name
PIP4K2C (PIP5K2C)
Protein name
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Names
Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
pon:100174032
EC number
2.7.1.149: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R488

Entry ID Method Resolution Chain Position Source
AF-Q5R488-F1 Predicted AlphaFoldDB

No variants for Q5R488

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R488

No associated diseases with Q5R488

1 regional properties for Q5R488

Type Name Position InterPro Accession
domain Phosphatidylinositol-4-phosphate 5-kinase, core 43 - 421 IPR002498

Functions

Description
EC Number 2.7.1.149 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endoplasmic reticulum
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

4 GO annotations of biological process

Name Definition
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSSVPPAT VSAATTGPGP GFGFASKTKK KHFVQQEVKV FRAADPLVGV FLWGVAHSIN
70 80 90 100 110 120
ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF KEYCPQVFRN LRDRFGIDDQ
130 140 150 160 170 180
DYLVSLTRNP PSESEGSDGR FLICYDRTLV IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT
190 200 210 220 230 240
LLPQFLGMYR VSVDNEDSYM LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL
250 260 270 280 290 300
KGMDFLNKNQ KVYIGEDEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG
310 320 330 340 350 360
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF IDVHAIRSAE
370 380 390 400 410 420
GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI STVHPEQYAK RFLDFITNIF
A