Q5R422

PR
Gene name
ATP6V0A1
Protein name
V-type proton ATPase 116 kDa subunit a 1
Names
V-ATPase 116 kDa subunit a 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Species
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5R422

Entry ID Method Resolution Chain Position Source
AF-Q5R422-F1 Predicted AlphaFoldDB

No variants for Q5R422

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5R422

No associated diseases with Q5R422

No regional properties for Q5R422

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5R422

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

1 GO annotations of molecular function

Name Definition
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
70 80 90 100 110 120
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
130 140 150 160 170 180
NFLELTELKF ILRKTQQFFD EMADPDLLGE SSSLLEPSEM GRGTPLRLGF VAGVINRERI
190 200 210 220 230 240
PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
250 260 270 280 290 300
RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQMEDHRQ RVLQAAAKNI RVWFIKVRKM
310 320 330 340 350 360
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
370 380 390 400 410 420
PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDF GHGILMTLFA
430 440 450 460 470 480
VWMVLRESRI LSQKNENEMF STVFSGRYII LLMGVFSMYT GLIYNDCFSK SLNIFGSSWS
490 500 510 520 530 540
VRPMFTYNWT EETLRGNPVL QLNPALPGVF GGPYPFGIDP IWNIATNKLT FLNSFKMKMS
550 560 570 580 590 600
VILGIIHMLF GVSLSLFNHI YFKKPLNIYF GFIPEIIFMT SLFGYLVILI FYKWTAYDAH
610 620 630 640 650 660
TSENAPSLLI HFINMFLFSY PESGYSMLYS GQKGIQCFLV VVALLCVPWM LLFKPLVLRR
670 680 690 700 710 720
QYLRRKHLGT LNFGGIRVGN GPTEEDAEII QHDQLSTHSE DADEPTEDEV FDFGATMVHQ
730 740 750 760 770 780
AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWTMVI HIGLSVKSLA GGLVLFFFFT
790 800 810 820 830
AFATLTVAIL LIMEGLSAFL HALRLHWVEF QNKFYSGTGF KFLPFSFEHI REGKFGE