Q5R405
Gene name |
SUPT5H |
Protein name |
Transcription elongation factor SPT5 |
Names |
DRB sensitivity-inducing factor large subunit, DSIF large subunit |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174081 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5R405
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5R405-F1 | Predicted | AlphaFoldDB |
No variants for Q5R405
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5R405 | |||||
No associated diseases with Q5R405
17 regional properties for Q5R405
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NGN domain | 174 - 260 | IPR005100 |
| domain | KOW | 268 - 295 | IPR005824-1 |
| domain | KOW | 415 - 442 | IPR005824-2 |
| domain | KOW | 467 - 497 | IPR005824-3 |
| domain | KOW | 589 - 616 | IPR005824-4 |
| domain | KOW | 699 - 726 | IPR005824-5 |
| domain | KOW | 1030 - 1057 | IPR005824-6 |
| domain | NusG-like, N-terminal | 172 - 263 | IPR006645 |
| domain | Spt5 transcription elongation factor, N-terminal | 75 - 168 | IPR022581 |
| domain | Spt5 C-terminal domain | 768 - 904 | IPR024945 |
| domain | NGN domain, eukaryotic | 174 - 261 | IPR039385 |
| domain | Spt5, KOW domain repeat 1 | 272 - 309 | IPR041973 |
| domain | Spt5, KOW domain repeat 2 | 416 - 466 | IPR041975 |
| domain | Spt5, KOW domain repeat 3 | 467 - 517 | IPR041976 |
| domain | Spt5, KOW domain repeat 4 | 593 - 635 | IPR041977 |
| domain | Spt5, KOW domain repeat 5 | 698 - 747 | IPR041978 |
| domain | Spt5, KOW domain repeat 6 | 1024 - 1080 | IPR041980 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DSIF complex | A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription elongation | Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDSEDSNFS | EEEDSERSSD | GEEAEVEEER | RSAAGSEKEE | EPEEEEEEEE | EEEYDEEEEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDDDRPPKKP | RHGGFILDEA | DVDDEYEDED | QWEDGAEDIL | EKAPNIDNVV | LDEDRSGARR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQNLWRDQRE | EELGEYYMKK | YAKSSVGETV | YGGSDELSDD | ITQQQLLPGV | KDPNLWTVKC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KIGEERATAI | SLMRKFIAYQ | FTDTPLQIKS | VVAPEHVKGY | IYVEAYKQTH | VKQAIEGVGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRLGYWNQQM | VPIKEMTDVL | KVVKEVANLK | PKSWVRLKRG | IYKDDIAQVD | YVEPSQNTIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKMIPRIDYD | RIKARMSLKD | WFAKRKKFKR | PPQRLFDAEK | IRSLGGDVAS | DGDFLIFEGN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RYSRKGFLFK | SFAMSAVITE | GVKPTLSELE | KFEDQPEGID | LEVVTESTGR | EREHNFQPGD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NVEVCEGELI | NLQGKILSVD | GNKITIMPKH | EDLKDMLEFP | AQELRKYFKM | GDHVKVIAGR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FEGDTGLIVR | VEENFVILFS | DLTMHELKVL | PRDLQLCSET | ASGVDVGGQH | EWGELVQLDP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTVGVIVRLE | RETFQVLNMY | GKVVTVRHQA | VTRKKDNRFA | VALDSEQNNI | HVKDIVKVID |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GPHSGREGEI | RHLFRSFAFL | HCKKLVENGG | MFVCKTRHLV | LAGGSKPRDV | TNFTVGGFAP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MSPRISSPMH | PSAGGQRGGF | GSPGGGSGGM | SRGRGRRDNE | LIGQTVRISQ | GPYKGYIGVV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KDATESTARV | ELHSTCQTIS | VDRQRLTTVG | SRRPGGMTST | YGRTPMYGSQ | TPMYGSGSRT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PMYGSQTPLQ | DGSRTPHYGS | QTPLHDGSRT | PAQSGAWDPN | NPNTPSRAEE | EYEYAFDDEP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TPSPQAYGGT | PNPQTPGYPD | PSSPQVNPQY | NPQTPGTPAM | YNTDQFSPYA | APSPQGSYQP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SPSPQSYHQV | APSPAGYQNT | HSPASYHPTP | SPMAYQASPS | PSPVGYSPMT | PGAPSPGGYN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PHTPGSGIEQ | NSSDWVTTDI | QVKVRDTYLD | TQVVGQTGVI | RSVTGGMCSV | YLKDSEKVVS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ISSEHLEPIT | PTKNNKVKVI | LGEDREATGV | LLSIDGEDGI | VRMDPDEQLK | ILNLRFLGKL |
| LEA |