Q5QUB6

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
KEGG Pathway
ilo:IL0744
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

770-860 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5QUB6

Entry ID Method Resolution Chain Position Source
AF-Q5QUB6-F1 Predicted AlphaFoldDB

No variants for Q5QUB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5QUB6

No associated diseases with Q5QUB6

5 regional properties for Q5QUB6

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 613 - 803 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 13 - 124 IPR007695
domain DNA mismatch repair protein MutS, core 279 - 597 IPR007696
domain DNA mismatch repair protein MutS, connector domain 133 - 263 IPR007860
domain DNA mismatch repair protein MutS, clamp 433 - 523 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEFSDKQIQ SHTPMMQQYL RIKAEHADML LFYRMGDFYE LFFEDAKRSA QLLDISLTAR
70 80 90 100 110 120
GQSNGEPIPM AGVPYHAVEN YLARLVNMGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
130 140 150 160 170 180
VTDESLLAEK RQNLLVAICP LNPKQPEAEY AISSLELSSG RFWLTKAHSS EQLAAEMQRL
190 200 210 220 230 240
EPAELLYPES ISLAGLPLAK AKCKRRPAWE FEQQTAFMLL TRQFGTQHLE GFGIKNNEPT
250 260 270 280 290 300
LAAAGAILHY VKETQRAALP HIQALITEHP QDAIILDAAT RRNLELQQSM GEGDTHLSAV
310 320 330 340 350 360
LDKTVSAMGS RQFQRWLQRP IRNHQELNQR YDAVDALKEN LNFENIQLTL KQLADIERIV
370 380 390 400 410 420
ARVGLRSARP KDFARLRDSL AKIPEVRASL SHRSLSYLHD IIEPFPEVVD LLTKAVIEQP
430 440 450 460 470 480
PLLIRDGGVI AEGYDKELDE LRDLATGATD YLKQLEQRER ERSGIATLKV GYNRVHGYFI
490 500 510 520 530 540
EVSRQSSEAV PDDYQRRQTL KNTERYIIPE LKEHEDKVLN AQARSLAREK WLYDQLFEHL
550 560 570 580 590 600
LPQVTALQKS ASGLAQLDTL CCFARLADNY RYCRPQLQKE TSLIELEAAR HPVIEQLSDE
610 620 630 640 650 660
PFIANPMSLT PQQRMLMITG PNMGGKSTYM RQAALIVILA HMGCYVPADK AIIGDIDRIF
670 680 690 700 710 720
TRIGASDDLA SGRSTFMVEM TETANILHNA TAKSLVLMDE IGRGTSTYDG LSLAWSCADY
730 740 750 760 770 780
LSRQLQCLTL FATHYFELTE LAEELPATVN VHVDAKEHGD TIAFLHKVSP GAASQSFGLQ
790 800 810 820 830 840
VAKLAGVPEH VIHKAKQKLS ELEHTHHGGL NEPKQATMEL TPPPEAIPSH TEKRNPLLDE
850 860 870
LEQLDINDLT PKQALDILYQ WQQKQKGSTQ S