Q5Q9Z2

PR
Gene name
VHL
Protein name
von Hippel-Lindau disease tumor suppressor
Names
pVHL
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:494000
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5Q9Z2

Entry ID Method Resolution Chain Position Source
AF-Q5Q9Z2-F1 Predicted AlphaFoldDB

No variants for Q5Q9Z2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5Q9Z2

No associated diseases with Q5Q9Z2

3 regional properties for Q5Q9Z2

Type Name Position InterPro Accession
domain von Hippel-Lindau disease tumour suppressor, beta/alpha domain 64 - 203 IPR022772
domain von Hippel-Lindau disease tumour suppressor, alpha domain 156 - 204 IPR024048
domain von Hippel-Lindau disease tumour suppressor, beta domain 63 - 143 IPR024053

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Endoplasmic reticulum
  • Nucleus
  • Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated
  • Colocalizes with ADRB2 at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40337 VHL von Hippel-Lindau disease tumor suppressor Homo sapiens (Human) PR
P40338 Vhl von Hippel-Lindau disease tumor suppressor Mus musculus (Mouse) PR
Q64259 Vhl von Hippel-Lindau disease tumor suppressor Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPRKAGSVEE AEAGAEEVGA EEVGPEESGG EESGAEESGP EESDPEEPGA AAEMEAGQPR
70 80 90 100 110 120
PVLRSVNSCE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR
130 140 150 160 170 180
DAGTYDGLLV NQTELFVPSL NVDGQPIFAN ITLPVYTLKE RCLQVVRSLV KPENYRRLDI
190 200 210
VRSLYEDLED HPNVRKDLER LAQEHIENQR MEGETEDFN