Q5PQN4
Gene name |
Mdm1 |
Protein name |
Nuclear protein MDM1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:314859 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5PQN4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5PQN4-F1 | Predicted | AlphaFoldDB |
No variants for Q5PQN4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5PQN4 | |||||
No associated diseases with Q5PQN4
No regional properties for Q5PQN4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5PQN4 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriole | A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| non-motile cilium | A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of centriole replication | Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TC05 | MDM1 | Nuclear protein MDM1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVRFKGLSE | YQRNFLWKKS | YLSESYNPSV | GQKYTWAGLR | SDQLGITKEP | SFISKRRVPY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YDPQISKYLE | WNGTVRENDA | LAPPEPQIIR | TPKPQEAEQR | EDANHETVLP | QEASRVPKRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSHSADSRAE | GASDGVEKHQ | DVTKNHSLVN | ADVELRPSTK | PLPESIEPRL | DRHLRKKAGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVVPLNNALR | NSEYQRQFVW | KTCKETAPVC | AANQVFRNKS | QVIPQFQGNT | FIHESEYKRN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKGLTPVKEP | KLREYLKGNS | SFEILSPEKK | ADEPLDLEVD | MASEDSDQPI | KKPAPWRHQR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGKVNSEYRA | KFLSPAQYLY | KAGAWTRVKE | SLSHQGSLNA | MWYAEVKELR | EKAESYRKRV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QGTHFSRDHL | NQIMSDSNCC | WDVSSVASSE | GTISSNIQAL | DLAGDLTSHR | TLQKHPPTKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEKKVALAEQ | PLENTIRSLE | LPEAPTMARR | KLAWDAAEGT | QKEDTQEEPS | GEEDGREARG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KDKQVCAGEL | QKVDMQTSKA | DGPTEGSETS | SVSSGKGGRL | PTPRLRELGI | QRTHHDLTTP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVGGAVLVSP | AKAKPSALEQ | RRRPSSQDGL | ETLKKGITKK | GKHRPLSLLT | SPTAGMKTVD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PLPLRQDCDA | NVLRVAEGTL | PVLKNLDHQT | NTPGQPSPCT | LPYCHPSSRI | QGRLRDPEFQ |
| 670 | 680 | 690 | 700 | 710 | |
| HNIGKPRMNN | TQLLPHGAFN | DEDADRLSEI | SARSAVSSLQ | AFQTLARAQK | RKENFWGKP |