Q5PQ01

PR
Gene name
pip4k2c (pip5k2c)
Protein name
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Names
Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:496028
EC number
2.7.1.149: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5PQ01

Entry ID Method Resolution Chain Position Source
AF-Q5PQ01-F1 Predicted AlphaFoldDB

No variants for Q5PQ01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5PQ01

No associated diseases with Q5PQ01

1 regional properties for Q5PQ01

Type Name Position InterPro Accession
domain Phosphatidylinositol-4-phosphate 5-kinase, core 46 - 419 IPR002498

Functions

Description
EC Number 2.7.1.149 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endoplasmic reticulum
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSGAMPAV SSTSSSAAVG ILSATTAKTK TKKKHFVQQK VKVFRASDPL ISVLMWGVNH
70 80 90 100 110 120
SVNELIQVPV PVMLLPDDFK ANSKIKVTNH LFNRENLPSH FKFKDYCPQV FRNLRERFGI
130 140 150 160 170 180
DDQDFQVSLT RSSPYCESEG HDGRFLLSYD KTLVIKEISS EDVADMHIIL SHYHQHIVKC
190 200 210 220 230 240
HESTLLPQFL GMYRLSVDNE DSYIIVMRNM FSHRLTVHRK YDLKGSLVSR EASDKEKVKE
250 260 270 280 290 300
LPTLKDMDFL NKSQKVYVDE EQKRNFMEKL KRDVDFLVQL KLMDYSLLLG IHEVFRAEQE
310 320 330 340 350 360
EEEELEEDNA ENECSPHVNV GSYGTSPEGI AGYLNSHKPL GPGEFEPIID VYAIKSSDNA
370 380 390 400 410
PQKEVYFMGL IDILTHYDAK KKAAHAAKTV KHGAGAEIST VHPDQYGKRF LEFVTNIFA