Q5PAE7
Gene name |
ispH |
Protein name |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Names |
HMBPP reductase |
Species |
Anaplasma marginale (strain St Maries) |
KEGG Pathway |
ama:AM804 |
EC number |
1.17.7.4: With an iron-sulfur protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5PAE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5PAE7-F1 | Predicted | AlphaFoldDB |
No variants for Q5PAE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5PAE7 | |||||
No associated diseases with Q5PAE7
No regional properties for Q5PAE7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5PAE7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.17.7.4 | With an iron-sulfur protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity | Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dimethylallyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate. |
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. |
| terpenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAVQQNHSV | CRGYCGVMLR | SRSGGFFRRG | FMLGNVEVIL | ARPRGFCAGV | ERAVRTLESV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASRYAGTREV | YALHEIVHNL | HVVNSFKKMG | VKFVSALHEV | PEGAVLVFSA | HGVSQQVKEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRRKGLTVVD | ATCPLVTKVH | LEIQRYDKSG | YQVILVGHKG | HREVEGSMGQ | VSNPVVLVQN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQDVQSIKIP | SAAKLAYVTQ | TTLSMDDTAE | IISALKLRFP | RIVGPDLRDI | CYATQNRQTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKAMSQMVDV | VLAIGSKNSS | NSNRLLDLAK | AQNARAYLID | SYRNIDLEWL | IGARRIGITA |
| 310 | 320 | 330 | 340 | ||
| GASAPEILVQ | EVIDYLGLHA | NLKVRTMDGV | SENITFKLPE | LD |