Q5P4A4

PR
Gene name
dnaE2
Protein name
Error-prone DNA polymerase
Names
Species
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp (strain EbN1))
KEGG Pathway
eba:ebA3077
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

878-953 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5P4A4

Entry ID Method Resolution Chain Position Source
AF-Q5P4A4-F1 Predicted AlphaFoldDB

No variants for Q5P4A4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5P4A4

No associated diseases with Q5P4A4

4 regional properties for Q5P4A4

Type Name Position InterPro Accession
domain Heat shock protein DnaJ, cysteine-rich domain 130 - 212 IPR001305
domain DnaJ domain 3 - 79 IPR001623
domain Chaperone DnaJ, C-terminal 118 - 333 IPR002939
conserved_site DnaJ domain, conserved site 45 - 64 IPR018253

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSAPPSPSP SPAPAYAELH CLTNFSFQRG ASHPEELVAR AAEAGYTALA ITDECSLAGV
70 80 90 100 110 120
VRAHQQLRRL ARPLKLLIGS ELRLVDGLRV VLLATDRAAY GRLARLITIG RRAATKGRYQ
130 140 150 160 170 180
LTCADLDRGI PGCLALVVPP DDRILDAAAL VADARWVGER FPDAAWLAVE LACGPDDGRR
190 200 210 220 230 240
LEALLAIASA AGLPPVAATG ALMHDPSRRA LADVLAALRL RVTIAEAGRA LAPNAERALH
250 260 270 280 290 300
ERAVLARRYP AELLAETLRI VARCHFRLDE LRYEYPAELV PDGETPASWL RRLVEDGLRW
310 320 330 340 350 360
RHGRPQDDLA PPKVRAQVEH ELALIAELGF EAYFLTVEDL VRFARGRGIL CQGRGSAANS
370 380 390 400 410 420
VICWALGITE VDPELGIMLV ERFISKERDE PPDIDVDFEH ERREEVIQYV YRKYGRERAA
430 440 450 460 470 480
LAATVIRYRA RSALRDVGRA LGLPPGQLER LARDRFWFDA GRIRPERLRE AGFDPASPGV
490 500 510 520 530 540
QRLATLTEAL VGFPRHLSQH VGGFVIARGR LDELVPVENA AMPERTVIQW DKDDLDALGL
550 560 570 580 590 600
LKIDVLALGM LSALRRSLAL VSTWRGRPFT LADIPREAPE VYRMLSEADS IGVFQIESRA
610 620 630 640 650 660
QMTMLPRLKP ARFYDLVVQV AIVRPGPIQG GMVHPYLQAR ARIERDEPVS YPQPHCPDAD
670 680 690 700 710 720
ADGTCVPRPD DVRRVLERTL GVPIFQEQVM QLAVVAAGFT PGEADQLRRA MGAFRRHGEL
730 740 750 760 770 780
ERYRAKLLAG MAARGYRAEF AERLCDQIEG FGSYGFPESH AASFALLVYC SAWLKCCEPA
790 800 810 820 830 840
AFLCGLLNSQ PMGFYAPSQL IQDARRHGVV VLGAEVTASD WDCTLEALPD ASPGAAPAVR
850 860 870 880 890 900
LGLQLVKGFG REAAMRIVAA RTERPFPNVD ELALRARLDA AALKRLAEAG ALEPLAGHRR
910 920 930 940 950 960
QALWQAAAGH APEGVLRGAR IAEPRAELAA PSEAQELVAD YARLGFTLGR HPLALLRAKL
970 980 990 1000 1010 1020
TTLRFVTAAE IRDYPDRKLA RIAGLVTCRQ RPGTAKGTLF LTVEDETGLA NVIVQAELVE
1030 1040 1050 1060
RQRREVLGAR LLGVFGQIRS KGQVVHLLAQ RLVDHSALLG ALEARSRDFQ