Q5NVR0
Gene name |
HMCES |
Protein name |
Abasic site processing protein HMCES |
Names |
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1 |
Species |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
KEGG Pathway |
pon:100174100 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5NVR0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5NVR0-F1 | Predicted | AlphaFoldDB |
No variants for Q5NVR0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5NVR0 | |||||
No associated diseases with Q5NVR0
No regional properties for Q5NVR0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5NVR0 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| replication fork | The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| positive regulation of isotype switching | Any process that activates or increases the frequency, rate or extent of isotype switching. |
| protein-DNA covalent cross-linking | The formation of a covalent cross-link between DNA and a protein. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCGRTSCHLP | RDVLTRACAY | QDRRGQQRLP | EWRDPDKYCP | SYNKSPQSNS | PVLLSRLHFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDADSSERII | APMRWGLVPS | WFKESDPSKL | QFNTTNCRND | TIMEKRSFKV | PLGKGRRCVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LADGFYEWQR | CQGTNQRQPY | FIYFPQIKTE | KSGSIGAADS | PENWGKVWDN | WRLLTMAGIF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DCWEPPEGGD | VLYSYTIITV | DSCKGLSDIH | HRMPAILDGE | EAVSKWLDFG | KVSTQEALKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IHPTENITFH | AVSSVVNNSR | NNTPECLAPV | DLVVRKELKA | SGSSQRMLQW | LATKSPKKED |
| 310 | 320 | 330 | 340 | 350 | |
| SKTPQKEESD | VPQWSSQFLQ | KSPLPTKRGT | AGLLEQWLKR | EKEEEPVAKR | PYSQ |