Q5NPH1

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Zymomonas mobilis subsp mobilis (strain ATCC 31821 / ZM4 / CP4)
KEGG Pathway
zmo:ZMO0765
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5NPH1

Entry ID Method Resolution Chain Position Source
AF-Q5NPH1-F1 Predicted AlphaFoldDB

No variants for Q5NPH1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5NPH1

No associated diseases with Q5NPH1

7 regional properties for Q5NPH1

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 347 - 550 IPR002314
domain TGS 3 - 64 IPR004095
domain Anticodon-binding 562 - 651 IPR004154
domain Aminoacyl-tRNA synthetase, class II 249 - 555 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 174 - 225 IPR012947
domain Threonine-tRNA ligase catalytic core domain 249 - 560 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 560 - 650 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEKIRITLI DNSEREVLQG TTTTQIAASI STSLAKKALA ARFNGQMIDL SQPLLEDGRL
70 80 90 100 110 120
EIITAENEAE ALELVRHDYA HILAEAVQKL FPGTQITFGP VTDDGFYYDF APKDRPFTEE
130 140 150 160 170 180
DLPLIEAEMR KIIAQNNALV REVWERDKLI SLWESQGEKF KAEWAKELPE GQELTIYRAG
190 200 210 220 230 240
EWFDMCRGPH LPSTGKLDPK AFKLTRVSGA YWRGDQNNAM LSRIYGTGWL NAKQLKAHLE
250 260 270 280 290 300
RLEEAQKRDH RRLGQEMDLF HLQQEAQGSV FWHPNGYTIW LQLEAYLRRR MKNANYKEVK
310 320 330 340 350 360
TPQLMDAALW EASGHWGKFR ENMFVVPDEI PSTDPDKPVL SGKGNLMALK PMNCPAHIQI
370 380 390 400 410 420
FKQGIRSYRE LPLRMLEFGC CHRNEAHGAL HGLMRVRQLT QDDAHIFCTA EQIVTETKDF
430 440 450 460 470 480
VNLLDSIYRD LGFTSYAVKL SLRPELRAGD DELWDNAENG LRSALEQVGI TDYEELPGEG
490 500 510 520 530 540
AFYGPKLEFH LTDAIGRTWQ CGTLQLDYVL PERLDASYVA EDGSRKRPVM LHRAIIGTFE
550 560 570 580 590 600
RFIGILIEHH AGRFPLWMAP VQAVVATIVS EADSFAESVV EKMKAAGLRV VSDIRNEKIN
610 620 630 640 650
YKIREHSLTK VPNILVVGKR EAEEGKVAIR KLGSRDQIIL SVDEAIALLL EEATPPDLK