Q5NDE6

PR
Gene name
pomgnt2 (ago61, gtdc2, TEgg056h10.1)
Protein name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Names
POMGnT2, Extracellular O-linked N-acetylglucosamine transferase-like, Glycosyltransferase-like domain-containing protein 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:496628
EC number
2.4.1.312: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5NDE6

Entry ID Method Resolution Chain Position Source
AF-Q5NDE6-F1 Predicted AlphaFoldDB

No variants for Q5NDE6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5NDE6

No associated diseases with Q5NDE6

4 regional properties for Q5NDE6

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 6 - 238 IPR003439
domain AAA+ ATPase domain 32 - 215 IPR003593
domain Transport-associated OB, type 2 276 - 344 IPR013611
conserved_site ABC transporter-like, conserved site 138 - 152 IPR017871

Functions

Description
EC Number 2.4.1.312 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
protein O-GlcNAc transferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + -3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + -3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

3 GO annotations of biological process

Name Definition
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNISAVFNAL LVSIMAAVLW KHVKLLEQFY VIEEELELTR QSQELSQVRI DYQAALQALV
70 80 90 100 110 120
EDGTRMVCSG RMHTDRVCRF ESLCYSTEAE EFVFFHSNSS IMLPNLGPRR FQPALLDLSS
130 140 150 160 170 180
VDDHNTQYFN FIELPAAALK FMPKPVFVPD VALIMNRFNP DNLMHVFHDD LIPIFYTIQQ
190 200 210 220 230 240
FADLDFESRL FFMEGWNEGL HFELYKFMSN KQPLLKEQLK TLGRLLCFTK SYVGLSKITT
250 260 270 280 290 300
WYQYGFVQPQ GPKANILVSG NEIRHFAKFM MGKLNITKDQ NAAEAYIVLF SRSMNRLIVN
310 320 330 340 350 360
EAELLLALAQ EFQMKTITVS LEDHSFADIV RLISNATMLV SMHGAQLITS LFLPKGAIVV
370 380 390 400 410 420
ELFPYGVNPE HYTPYKTLST LPGMELQYVA WQNTEEENTI AYPNRPWEQG GIVHLDKTEQ
430 440 450 460 470 480
ERIKKSKEVP RHLCCRNPEW LFRIYQDTKV NISSLIQVIK SKTKLGSRRQ KWTQGLYPGK
490 500 510 520 530 540
VRESKCQASA QGTGEAKLFV SWQIPWNLKF LKVRDVKYEV WIQEQGENSY MPYILSQQNY
550 560 570
TFSENIKPLT TYLVWIRCIF NKTLLGPFAE VLVCNT