Q5N1X6

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
KEGG Pathway
syc:syc1504_d
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5N1X6

Entry ID Method Resolution Chain Position Source
AF-Q5N1X6-F1 Predicted AlphaFoldDB

No variants for Q5N1X6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5N1X6

No associated diseases with Q5N1X6

6 regional properties for Q5N1X6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 289 - 497 IPR002314
domain Anticodon-binding 509 - 597 IPR004154
domain Aminoacyl-tRNA synthetase, class II 231 - 514 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 124 - 176 IPR012947
domain Threonine-tRNA ligase catalytic core domain 200 - 507 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 507 - 596 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPLMVQSAPS TEAIQLPKTS ESAQLKRIRH TMSHVMAMAV QKLFPKAQVT IGPWTETGFY
70 80 90 100 110 120
YDFDTPEPFT EADLKAIKKE MVKIIQQKLP VVREEVSREE AQQRIEALGE PYKLEILQGL
130 140 150 160 170 180
TEPITLYHLG DRWWDLCAGP HVETTAELNP KAFDLESVAG AYWRGDETKA QLQRIYGTAW
190 200 210 220 230 240
ETPEQLTEYK RRKEEALKRD HRKLGRELGL FLFADPVGPG LPLWTPKGTI LRSTLEDFLK
250 260 270 280 290 300
QEQMKRGYQS VVTPHLARVD LFKVSGHWQN YREDMFPMMA EDDEARGLEQ GFVLKPMNCP
310 320 330 340 350 360
FHIQIYKNEL RSYRELPIRL AEFGTVYRYE QSGELGGLTR VRGFTVDDSH LFVRPDQLAS
370 380 390 400 410 420
EFLSVVDLIL SVFKALNLKK FKARLSFRDP ESDKYIGSDD VWEKAESAIQ AAAETLGMDY
430 440 450 460 470 480
FIGVGEAAFY GPKLDFIFQD ALDREWQLGT VQVDYNLPER FDLEYVAEDG SRQRPVMIHR
490 500 510 520 530 540
APFGSLERLI GILIEEYAGD FPLWLAPEQI RLLPVTETVL DYCQQVADQL RAIGVRVQVD
550 560 570 580 590 600
CSGDRLGKLI RNAEKAKIPV MAVIGAQEAE SETLSIRTRA TGDLGSLTVA DLTKRLSSAI
AEKLPHL