Q5M868

PR
Gene name
Gba2
Protein name
Non-lysosomal glucosylceramidase
Names
NLGase, Beta-glucocerebrosidase 2, Beta-glucosidase 2, Bile acid beta-glucosidase GBA2, Bile acid glucosyl transferase GBA2, Cholesterol glucosyltransferase GBA2, Cholesteryl-beta-glucosidase GBA2, Glucosylceramidase 2, Non-lysosomal cholesterol glycosyltransferase, Non-lysosomal galactosylceramidase, Non-lysosomal glycosylceramidase
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
3.2.1.45: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5M868

Entry ID Method Resolution Chain Position Source
AF-Q5M868-F1 Predicted AlphaFoldDB

No variants for Q5M868

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5M868

No associated diseases with Q5M868

2 regional properties for Q5M868

Type Name Position InterPro Accession
domain Glycosyl-hydrolase family 116, catalytic region 512 - 877 IPR006775
domain Glycosyl-hydrolase family 116, N-terminal 142 - 446 IPR024462

Functions

Description
EC Number 3.2.1.45 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Localization to the plasma membrane and alternative topologies have also been reported
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of Golgi membrane The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
glucosylceramidase activity Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
steryl-beta-glucosidase activity Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol.

11 GO annotations of biological process

Name Definition
bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.
glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule.
regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
regulation of membrane lipid distribution Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.
regulation of microtubule polymerization Any process that modulates the frequency, rate or extent of microtubule polymerization.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HCG7 GBA2 Non-lysosomal glucosylceramidase Homo sapiens (Human) PR
Q69ZF3 Gba2 Non-lysosomal glucosylceramidase Mus musculus (Mouse) PR
10 20 30 40 50 60
MVTCVPASEQ IGCAERDSQI YSEDTGGTEA VRVTDCRSPE DSGPQNEPGY CNSEDSGQLM
70 80 90 100 110 120
ASYEGKARGY QVPPFGWRIC LAHEFAEKRK PFQANNVSLS NLVKHFGMGL RYLKWWYRKT
130 140 150 160 170 180
QVEKKTPFID MFNSVPLRQI YGCPLGGIGG GTITRGWRGQ FCRWQLNPGM YQHQTVIADQ
190 200 210 220 230 240
FIVCLRRDGR TVYQQVLSLE LPSVLRSWNW GLCGYFAFYH ALYPRAWTVY QLPGQNVTLT
250 260 270 280 290 300
CRQITPILPH DYQDSSLPVG VFVWDVENEG DETLDVSIMF SMRNGLGGED DAAGGLWNEP
310 320 330 340 350 360
FRLEQDGTTV QGLLLHHPTP PNPYTMAVAA RHTADTTVTY TTAFDPDSTG QQVWQDLLQD
370 380 390 400 410 420
GQLDSPAGQS TPTQRGEGVA GAVCASSKLL PRGRCCLEFS LAWDMPRIMF GAKGQVHYRR
430 440 450 460 470 480
YTRFFGSDGD VAPALSHYAL CQYAGWENSI SAWQNPVLDD RSLPAWYKSA LFNELYFLAD
490 500 510 520 530 540
GGTVWLEVPE DSLPEELGGS MYQLRPILQD YGRFGYLEGQ EYRMYNTYDV HFYASFALVM
550 560 570 580 590 600
LWPKLELSLQ YDMALATFKE DLTRRRYLMS GVVAPVKRRN VIPHDIGDPD DEPWLRVNAY
610 620 630 640 650 660
LIHDTADWKD LNLKFVLQVY RDYYLTGDQG FLKDMWPVCL AVMESEMKFD KDQDGLIENG
670 680 690 700 710 720
GYADQTYDGW VTTGPSAYCG GLWLAAVAVM VQMAVLCGAQ DVQDKFSSIL CRGREAYERL
730 740 750 760 770 780
LWNGRYYNYD SSSQPQSRSV MSDQCAGQWF LRACGLGEGD TEVFPTLHVV RALKTIFELN
790 800 810 820 830 840
VQAFAGGAMG AVNGMQPHGV PDRSSVQSDE VWVGVVYGLA ATMIQEGLTW EGFRTAEGCY
850 860 870 880 890 900
RTVWERLGLA FQTPEAYCQQ RVFRSLAYMR PLSIWAMQLA LQQQQHKKNS SRPAVTQGTA
910
PSQPECGPKR SL