Q5M0B4

PR
Gene name
glyA
Protein name
Serine hydroxymethyltransferase
Names
SHMT, Serine methylase
Species
Streptococcus thermophilus (strain CNRZ 1066)
KEGG Pathway
stc:str0755
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

188-262 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for Q5M0B4

Entry ID Method Resolution Chain Position Source
4WXB X-ray 205 A A/B/C/D 1-416 PDB
4WXF X-ray 240 A A/C 1-416 PDB
4WXG X-ray 200 A A/C 1-416 PDB
6TGH X-ray 212 A A/B/C/D 2-416 PDB
6TI1 X-ray 200 A A/C 1-416 PDB
6TI3 X-ray 196 A A/B/C/D 1-416 PDB
6YRW X-ray 250 A A/B/C/D 1-416 PDB
AF-Q5M0B4-F1 Predicted AlphaFoldDB

No variants for Q5M0B4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5M0B4

No associated diseases with Q5M0B4

2 regional properties for Q5M0B4

Type Name Position InterPro Accession
binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site 222 - 238 IPR019798
domain Serine hydroxymethyltransferase-like domain 10 - 386 IPR039429

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

2 GO annotations of biological process

Name Definition
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIFDKEDYKA FDPELWNAID AEAERQQNNI ELIASENVVS KAVMAAQGTL LTNKYAEGYP
70 80 90 100 110 120
GKRYYGGTAV IDVVETLAIE RAKKLFGAKF ANVQPHSGSQ ANAAVYMSLI QPGDTVMGMD
130 140 150 160 170 180
LSAGGHLTHG APVSFSGKTY NFVSYNVDKE SELLDYDAIL AQAKEVRPKL IVAGASAYSR
190 200 210 220 230 240
IIDFAKFREI ADAVGAYLMV DMAHIAGLVA SGHHPSPVPY AHVTTTTTHK TLRGPRGGLI
250 260 270 280 290 300
LTDDEDIAKK LNSAVFPGLQ GGPLEHVIAA KAVALKEALD PAFKEYGENV IKNAAAMADV
310 320 330 340 350 360
FNQHPDFRVI SGGTNNHLFL VDVTKVVENG KVAQNVLEEV NITLNKNSIP YEQLSPFKTS
370 380 390 400 410
GIRVGSPAIT SRGMGEAESR QIAEWMVEAL ENHDKPEVLE RIRGDVKVLT DAFPLY