Q5LTH8

PR
Gene name
lcdH (SPO1436)
Protein name
L-carnitine dehydrogenase
Names
CDH, L-CDH
Species
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
KEGG Pathway
sil:SPO1436
EC number
1.1.1.108: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5LTH8

Entry ID Method Resolution Chain Position Source
AF-Q5LTH8-F1 Predicted AlphaFoldDB

No variants for Q5LTH8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5LTH8

No associated diseases with Q5LTH8

2 regional properties for Q5LTH8

Type Name Position InterPro Accession
domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal 184 - 248 IPR006108
domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding 4 - 178 IPR006176

Functions

Description
EC Number 1.1.1.108 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
carnitine 3-dehydrogenase activity Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH.
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

2 GO annotations of biological process

Name Definition
carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTAAIIGGG VIGGGWAARF LLNGWDVRVF DPDPEAERKI GEVLANARRS LPGLSDMPLP
70 80 90 100 110 120
PEGKLSFHAD LGEAVTGAAW IQESVPERLD LKLKVYRSIQ EACDPGAILG SSTSGFKPSE
130 140 150 160 170 180
LQEGALRPGQ IVVTHPFNPV YLLPLIELVT TPENSPEMIE RAKEIMRGLG QFPLHVRKEI
190 200 210 220 230 240
DAHIADRFLE AVWREALWLV KDGIATTEEI DEAIRMGFGI RWAQMGLFET YRVAGGEAGM
250 260 270 280 290 300
KHFMAQFGPC LSWPWTKLMD VPEFTDELVD LIAGQSDAQS GHHTIRELER IRDNNLVGMM
310 320 330 340 350 360
RALKAQNWGA GAVLNKHDAA LKPKALPDLD TADLTQPILT LSRAVPLDWT DYNGHMTESK
370 380 390 400 410 420
YLEAFANSTD RFMEIIGCDA DYIAAGGSYF TAETHIRHLD EAHAGARIRV ETQMLLGQGK
430 440 450 460 470 480
KLHLFHRMYE GDKLLATGES FLLHVSLETR KPCAPSPEIE AAMARIAEAQ AGLSYPEGAG
SAIRKPA