Q5LH04

PR
Gene name
menG
Protein name
Demethylmenaquinone methyltransferase
Names
Species
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)
KEGG Pathway
bfs:BF9343_0801
EC number
2.1.1.163: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5LH04

Entry ID Method Resolution Chain Position Source
AF-Q5LH04-F1 Predicted AlphaFoldDB

No variants for Q5LH04

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5LH04

No associated diseases with Q5LH04

1 regional properties for Q5LH04

Type Name Position InterPro Accession
conserved_site UbiE/COQ5 methyltransferase, conserved site 32 - 47 IPR023576

Functions

Description
EC Number 2.1.1.163 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
demethylmenaquinone methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine.
S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol.
S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+.
S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine.

2 GO annotations of biological process

Name Definition
menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNYPQEKIKP YSNDGKKSEQ VEQMFDNIAP AYDQLNHTLS LGIDRSWRRK AINWLKPFRP
70 80 90 100 110 120
QQIMDVATGT GDFAILACHE LQPEQLIGTD ISEGMMNVGR EKVKKEGLSE KISFAREDCT
130 140 150 160 170 180
SLSFADNRFD AITVAFGIRN FEDLDKGLSE MYRVLKTGGH LVILELTTPD RFPMKQMFTI
190 200 210 220 230 240
YSKIVIPTLG KLLSKDNSAY SYLPQTIKAF PQGEVMKNVI SRVGFSQVQF RRLTFGICTL
YTATK