Q5L6P4
Gene name |
glyA |
Protein name |
Serine hydroxymethyltransferase |
Names |
SHMT, Serine methylase |
Species |
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus) |
KEGG Pathway |
cab:CAB220 |
EC number |
2.1.2.1: Hydroxymethyl-, formyl- and related transferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5L6P4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5L6P4-F1 | Predicted | AlphaFoldDB |
No variants for Q5L6P4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5L6P4 | |||||
No associated diseases with Q5L6P4
4 regional properties for Q5L6P4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 11 - 22 | IPR001412 |
| domain | Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain | 4 - 323 | IPR020058 |
| domain | Glutamyl-tRNA synthetase | 5 - 331 | IPR033910 |
| domain | Aminoacyl-tRNA synthetase, class I, anticodon-binding | 344 - 484 | IPR045462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.2.1 | Hydroxymethyl-, formyl- and related transferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glycine hydroxymethyltransferase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glycine biosynthetic process from serine | The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. |
| tetrahydrofolate interconversion | The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSLLHKFLE | NASGKKGQDL | ASTAYLAALD | HLLHSFPSIG | KSIIDELKSQ | RSRLKMIASE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NYASISVQLA | MGNLLTDKYC | EGSPFKRFYS | CCENVDAIEW | ECVETAKELF | GAESAFVQPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGADANLLAI | MAIITQKIQG | PAVKRLGYKT | INDLTDKEYT | ELKAEIGSHV | CLGPSLNSGG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLTHGTVRLN | IMSKLMRCVP | YEVNKKTECF | DYSEIARLVR | TYKPTVLIAG | YSSYSRRLNF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STLKQIADDC | GAVLWVDMAH | FAGLVAGGVF | IEEENPIPFA | DIITTTTHKT | LRGPRGGLVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASKEYDAVIN | RACPLMMGGP | LPHVIAAKAV | ALKEALTVDF | KKYAHQVVDN | ARTLAEHFQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QGLRLLTGGT | DNHMLIIDLT | SLGISGRIAE | DILSSVGIAV | NRNTIPSDAV | GKWDTSGIRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTPALTTLGM | GSDEMEEVAN | IIVKVLRNIT | LRRNADDSFS | KSEGELPENI | AEEARARVAG |
| 490 | |||||
| LLSRFPLYPE | IDLETLV |