Q5L659

PR
Gene name
lepA
Protein name
Elongation factor 4
Names
EF-4, Ribosomal back-translocase LepA
Species
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
KEGG Pathway
cab:CAB419
EC number
3.6.5.n1: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

543-602 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5L659

Entry ID Method Resolution Chain Position Source
AF-Q5L659-F1 Predicted AlphaFoldDB

No variants for Q5L659

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5L659

No associated diseases with Q5L659

6 regional properties for Q5L659

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 405 - 484 IPR000640
domain Translational (tr)-type GTP-binding domain 7 - 188 IPR000795
domain Translation elongation factor EFTu-like, domain 2 211 - 281 IPR004161
domain Small GTP-binding protein domain 10 - 179 IPR005225
domain GTP-binding protein LepA, C-terminal 494 - 600 IPR013842
domain Elongation factor 4, domain IV 407 - 484 IPR035654

Functions

Description
EC Number 3.6.5.n1 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosome binding Binding to a ribosome.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

1 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKEYKLENIR NFSIIAHIDH GKSTIADRLL ESTSTVEQRE MREQLLDSMD LERERGITIK
70 80 90 100 110 120
AHPVTMYYKY NGEVYQLNLI DTPGHVDFSY EVSRSLTACE GALLIVDAAQ GVQAQSLANV
130 140 150 160 170 180
YLALERDLEI IPILNKIDLP AANPEKIRKQ IEDYIGLDTT HAIACSAKTG EGISEILEAI
190 200 210 220 230 240
VELIPPPKSP EETELKALIF DSHYDPYVGI MVYVRVMSGE IKKGDRITFM ATKGSSFEVL
250 260 270 280 290 300
GVGAFLPEAT LIEGSLRAGQ VGYFIANLKK VKDVKIGDTV TTVKHSAKVP LEGFKEINPV
310 320 330 340 350 360
MFAGIYPIDS SDFDALKDAL SRLQLNDSAL TIEQESSHSL GFGFRCGFLG LLHLEIVFER
370 380 390 400 410 420
IIREFDLDII ATAPSVIYKV VLKNGKTLFI DNPTAYPDPS IIEHMEEPWV HVNIITPQEY
430 440 450 460 470 480
LSSIMNLCLD KRGVCLKTEM LDQHRLVLSY DLPLNEIVSD FNDKLKSVTK GYGSFDYRLG
490 500 510 520 530 540
DYRKGSIIKL EILINDEPVD AFSCLVHRDK AEARGRSICE KLVGVIPQQL FKIPIQAAIN
550 560 570 580 590 600
KKVIARETIR ALSKNVTAKC YGGDITRKRK LWEKQKKGKK RMKEFGKVSI PNTAFIEVLK
ID