Q5L5Q6

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
KEGG Pathway
cab:CAB585
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

238-322 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5L5Q6

Entry ID Method Resolution Chain Position Source
AF-Q5L5Q6-F1 Predicted AlphaFoldDB

No variants for Q5L5Q6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5L5Q6

No associated diseases with Q5L5Q6

4 regional properties for Q5L5Q6

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 675 - 784 IPR013155
domain Methionyl/Leucyl tRNA synthetase 38 - 171 IPR015413
domain Leucyl-tRNA synthetase, editing domain 219 - 364 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYDPSLIEK KWQQFWKEHK SFKADETADK PKYYVLDMFP YPSGAGLHVG HLIGYTATDI
70 80 90 100 110 120
VARYKRAKGF SVLHPMGWDS FGLPAEQYAV RTGTHPRETT KKNIENFRKQ LSAMGFSYDE
130 140 150 160 170 180
AREFATSDPE YYRWTQKLFL FLYEKGLAYM ADMAVNYCEE LGTVLANEEV ENGLSIEGGY
190 200 210 220 230 240
PVERRMLRQW ILRITAYADQ LLQGLEDLDW PENVKQLQRN WIGKSEGALL RFVVDKDKCL
250 260 270 280 290 300
EVFTTRPDTL CGVSFLVMAP EHPEIQQLVS EEQRSAVESY IRCAQSKSER ERISETKVKS
310 320 330 340 350 360
GVFTGAYAKH AITGAALPIW VSDYVIMGYG SGVVMGVPAH DERDREFANA FALPIDEVLD
370 380 390 400 410 420
ENEHCINSNH GDFLLNGLQG KEASDYVIAY LQKRNLGEAK VMYKLHDWLF SRQRYWGEPI
430 440 450 460 470 480
PIIHFEDGTC RPLEDDELPL LPPEIQDYRP KGFGQGPLAK VKEWVDIHDV KTQRPGRRET
490 500 510 520 530 540
HTMPQWAGSC WYYLRFCDAH NSQAPWSHEN ERYWMPVDLY IGGAEHAVLH LLYSRFWHRV
550 560 570 580 590 600
FYEAGLVSTP EPFKKLINQG LVLATSYRIP GKGYVHPEDA REDNGKWTTA SGEELEVRQE
610 620 630 640 650 660
KMSKSKLNGV DPQILIDEFG ADALRMYAMF SGPLDKNKLW CNQGVSGCRR FLNRFYELAT
670 680 690 700 710 720
SSAVQDIDDP KGMALAHRLV HKVGEDIEKM SLNTIPSSFM EFINEFAKLD TYSKSALSMV
730 740 750 760 770 780
VRALAPIAPH ISEELWTVLG YAPGIDNAGW PEVDPKYLED TSVTFVIQVN GKLRARLDMD
790 800 810
KNTSQEDILS AARESVAKYL EDKEIKKEVF VPNRLVNFVL