Q5KA65

PR
Gene name
XPT1 (CNJ02890)
Protein name
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase
Names
Xylosylphosphotransferase 1
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
cne:CNJ02890
EC number
2.7.8.32: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-436 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5KA65

Entry ID Method Resolution Chain Position Source
AF-Q5KA65-F1 Predicted AlphaFoldDB

No variants for Q5KA65

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5KA65

No associated diseases with Q5KA65

2 regional properties for Q5KA65

Type Name Position InterPro Accession
domain Stealth protein CR4, conserved region 4 810 - 863 IPR031356
domain Stealth protein CR3, conserved region 3 504 - 555 IPR031357

Functions

Description
EC Number 2.7.8.32 Transferases for other substituted phosphate groups
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.

3 GO annotations of biological process

Name Definition
carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y.
D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.
N-glycan processing to lysosome The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPTALPPLR PPAQPYDSYS SSLSPSSPRF HPASAPHGRR APSPSRLESL LDAPHAPARS
70 80 90 100 110 120
PSRKIRSALS RHIRPHLTPR TLTPLLLWTL ALWLVHHFLF PFSSPLAALS RPKAEQHFLS
130 140 150 160 170 180
TTFPPPPQRL GDDRLDSVDP RWRAFHPLPP PEPPFPRLRP TRFLPPQCLE QWFADGETLC
190 200 210 220 230 240
GAKEMGEEET LDATWLWVNG SDHRWRDSMA EWREKENVNS PERHFREQNE LVHSMRSVLD
250 260 270 280 290 300
ALPGHLRTFH LILADYPFNY PEDLDLVPPS IIPDLEVAAS KGGQGRRHPR ELARAPASVS
310 320 330 340 350 360
NLTERLTPES ISPSLARHLQ SEWRILQTPT WLDFSRRDPS DPSHPFHPYS VSKAGEMRQH
370 380 390 400 410 420
YAEASYPTLR YASHWEVFHI PSVDRDGREE LMGEREWREN EWKKKALPSF NSMAIESRIG
430 440 450 460 470 480
WLPGLADAII ALNDDFFLLR PHAVSDFHSP LYGSVIRFEH SYNQQVKPDV EKNHINDPGE
490 500 510 520 530 540
MGGLYHANAL LSRRFPHRLR PYFAHVPKVI TRGLHHEASL MFQEALTLSS TRKFREMKIG
550 560 570 580 590 600
EGDVQMQWLL TSLRVERWRE ALLWTWVVAN MGTLSGSHDR WDSDTRSAIK HLFGFTEDDD
610 620 630 640 650 660
DVVKIEVHRG ERWTLEPGRM QKVFHQAGWE APKATEFLFS SMDGIMPPLL RSGEDPSQND
670 680 690 700 710 720
RCIIDLNRCF GVFWTRQEDV LSADMMKRLT FQYPECGDCM IMALVTASGT LGLNAFFPPK
730 740 750 760 770 780
ETTITAPELG PGDAYPKYLP PPHLPLTPTW HEADYSLSNI LSTTALPGEQ VDIRQYCMRL
790 800 810 820 830 840
LSRYLYLDAK SVSHFHMMKS AEHAKRVFKM IQDNPKVSIL GMNDDIESDY DEVKRLMNEW
850 860
FEMRWPRKAV WERDWDPVKD RYHD