AiPD: Autoinhibited Protein Database

Q5JUK9

Gene name	PAGE3 (GAGED1)
Protein name	P antigen family member 3
Names	PAGE-3, G antigen family D member 1, Prostate-associated gene 3 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:139793
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-80 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5JUK9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5JUK9-F1	Predicted				AlphaFoldDB

90 variants for Q5JUK9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1483560159 CA413363531	6	R>G		No	ClinGen TOPMed
CA10429084 rs144687253	10	R>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10429085 rs144687253	10	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs371522940 CA10429082	11	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs371522940 CA413363499	11	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1443572899 CA413363496	11	S>Y		No	ClinGen TOPMed
rs918286227 CA329213113	16	D>V		No	ClinGen TOPMed gnomAD
CA10429081 rs776828274	17	D>E		No	ClinGen ExAC
rs747352324 CA10429079	22	H>L		No	ClinGen ExAC TOPMed gnomAD
rs943832693 CA329213112	22	H>N		No	ClinGen Ensembl
rs1376744169 CA413363408	24	V>L		No	ClinGen TOPMed gnomAD
CA10429078 rs775868347	25	G>R		No	ClinGen ExAC gnomAD
CA329213111 rs890237153	26	A>T		No	ClinGen TOPMed gnomAD
CA10429077 rs772415771	27	V>M		No	ClinGen ExAC
rs774909688 CA10429056	29	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1359218103 CA413363357	31	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs149359953 CA10429054	34	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs754946853 CA10429053	34	S>T		No	ClinGen 1000Genomes ExAC gnomAD
rs4826381 VAR_027097 CA10429052	35	N>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA413363333 rs4826381	35	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1238133356 CA413363330	35	N>S		No	ClinGen TOPMed
TCGA novel	36	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413363314 rs1235192574	37	Q>P		No	ClinGen gnomAD
rs758205180 CA10429049	41	E>G		No	ClinGen ExAC gnomAD
CA413363275 rs1214170406	42	E>D		No	ClinGen gnomAD
rs750239248 CA10429048	43	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1182005651 CA413363267	44	P>T		No	ClinGen TOPMed
rs778884556 CA10429047	45	I>T		No	ClinGen ExAC gnomAD
CA329213068 rs938913372	45	I>V		No	ClinGen TOPMed
rs1248013121 CA413363253	46	E>A		No	ClinGen gnomAD
rs375864925 CA10429046	49	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10429045 rs753874324	52	P>A		No	ClinGen ExAC gnomAD
CA413363211 rs753874324	52	P>S		No	ClinGen ExAC gnomAD
CA10429044 rs2296807	53	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_027098 CA10429043 rs2296807	53	G>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752919528 CA10429042	55	E>G		No	ClinGen ExAC gnomAD
CA413363195 rs1351935102	55	E>K		No	ClinGen TOPMed gnomAD
rs1366637297 CA413363188	56	R>G		No	ClinGen gnomAD
rs1313962750 CA413363170	58	E>G		No	ClinGen TOPMed
CA10429041 rs372486004	58	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10429040 rs759924385	61	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1413719265 CA413363146	62	D>G		No	ClinGen gnomAD
CA413362949 rs1349804677	65	V>A		No	ClinGen gnomAD
CA10429025 rs752769657	67	G>D		No	ClinGen ExAC gnomAD
CA413362938 rs752769657	67	G>V		No	ClinGen ExAC gnomAD
rs767749041 CA10429024	69	A>E		No	ClinGen ExAC TOPMed gnomAD
CA413362931 rs1356262684	69	A>T		No	ClinGen TOPMed
CA10429023 rs769875193	71	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	72	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413362896 rs1555921142	74	E>G		No	ClinGen Ensembl
CA329212895 rs866801859	74	E>K		No	ClinGen Ensembl
CA10429021 rs751907829	76	T>A		No	ClinGen ExAC gnomAD
rs763489957 CA10429019	77	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763489957 CA413362881	77	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10429020 rs372514683	77	R>W		No	ClinGen ExAC gnomAD
rs773853906 CA10429018	78	S>P		No	ClinGen ExAC gnomAD
rs1569161911 CA413362863	80	T>S		No	ClinGen Ensembl
rs940816228 CA329212893	81	G>E		No	ClinGen TOPMed
CA10429017 rs748213304	81	G>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1198105134 CA413362854	82	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs138036236 CA10429015	84	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs771711717 CA10429014	84	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA329212892 rs952594646	86	D>N		No	ClinGen TOPMed gnomAD
CA10429011 rs770717075	87	G>S		No	ClinGen ExAC gnomAD
CA329212890 rs563855489	88	P>A		No	ClinGen Ensembl
TCGA novel	88	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10429010 rs188128595	88	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777668236 CA10429009	90	V>G		No	ClinGen ExAC gnomAD
rs756087250 CA10429008	91	K>N		No	ClinGen ExAC gnomAD
rs1464703821 CA413362803	91	K>Q		No	ClinGen gnomAD
TCGA novel	95	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	96	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	99	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413362749 rs1177846438	99	E>K		No	ClinGen gnomAD
rs1424146198 CA413362738	100	P>L		No	ClinGen gnomAD
CA10429007 rs748219242	100	P>S		No	ClinGen ExAC gnomAD
rs1426475482 CA413362726	102	K>I		No	ClinGen TOPMed
rs375793042 CA10429006	103	I>M		No	ClinGen ESP ExAC gnomAD
CA10429005 rs755174299	104	P>A		No	ClinGen ExAC gnomAD
rs758627352 CA10429004	105	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA10429002 rs758824961	106	A>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766778317 CA10429003	106	A>S		No	ClinGen ExAC TOPMed gnomAD
rs766778317 CA413362704	106	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1442355425 CA413362700	107	G>R		No	ClinGen TOPMed
CA413362673 rs1158024326	109	G>E		No	ClinGen gnomAD
rs1378370842 CA413362676	109	G>R		No	ClinGen gnomAD
TCGA novel	110	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1601961570 CA413362657	111	P>L		No	ClinGen Ensembl
CA413362651 rs1258297362	112	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	113	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q5JUK9

1 regional properties for Q5JUK9

Type	Name	Position	InterPro Accession
domain	GAGE	1 - 113	IPR031320

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSGHQRTRSR	SRERRDDQDS	NHPVGAVVAQ	ELPSNDQLQQ	EEPPIESQDY	TPGQERDEGA
70	80	90	100	110
LDFQVLGLAA	YLWELTRSKT	GGERGDGPNV	KGEFLPNLEP	VKIPEAGEGQ	PSV