AiPD: Autoinhibited Protein Database

Q5JS54

Gene name	PSMG4 (C6orf86, PAC4)
Protein name	Proteasome assembly chaperone 4
Names	PAC-4, hPAC4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:389362
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-108 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

34-108 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q5JS54

Entry ID	Method	Resolution	Chain	Position	Source
5WTQ	X-ray	190 A	A/B/C/D	1-123	PDB
8QYJ	EM	273 A	M	1-123	PDB
AF-Q5JS54-F1	Predicted				AlphaFoldDB

88 variants for Q5JS54

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs976365457 CA133497155	2	E>D		No	ClinGen TOPMed
CA133497156 rs964160513	3	G>E		No	ClinGen TOPMed
rs1225739300 CA362594345	3	G>R		No	ClinGen TOPMed gnomAD
CA362594353 rs1433952308	4	L>R		No	ClinGen TOPMed
rs1178566454 CA362594350	4	L>V		No	ClinGen TOPMed
rs1189862491 CA362594354	5	V>I		No	ClinGen TOPMed
CA362594372 rs1272242573	8	A>T		No	ClinGen gnomAD
CA362594380 rs1205064975	9	G>S		No	ClinGen TOPMed
rs866206808 CA133497223	10	G>R		No	ClinGen Ensembl
rs751126684 CA362594407	13	S>C		No	ClinGen ExAC TOPMed gnomAD
CA3619410 rs751126684	13	S>F		No	ClinGen ExAC TOPMed gnomAD
CA362594404 rs1257226067	13	S>P		No	ClinGen TOPMed
rs201036341 COSM1222377 CA3619412	14	L>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA3619411 rs201036341	14	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362594414 rs1304692231	15	H>P		No	ClinGen TOPMed
CA362594434 rs75909236	17	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362594435 rs1473812732	18	S>G		No	ClinGen TOPMed
CA3619415 rs779454348	19	A>V		No	ClinGen ExAC gnomAD
CA362594463 rs1561839712	22	W>*		No	ClinGen Ensembl
CA3619416 rs746049177	23	E>G		No	ClinGen ExAC TOPMed gnomAD
CA362594480 rs1201680330	24	Q>L		No	ClinGen gnomAD
CA362594481 rs1201680330	24	Q>R		No	ClinGen gnomAD
CA133497303 rs940465427	26	V>D		No	ClinGen Ensembl
rs1187942350 CA362594503	28	F>L		No	ClinGen gnomAD
CA133497306 rs563530189	30	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3619417 rs563530189	30	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779985403 CA3619418	31	M>L		No	ClinGen ExAC
rs947831461 CA133497313	32	R>G		No	ClinGen TOPMed
rs947831461 CA362594530	32	R>W		No	ClinGen TOPMed
rs747181103 CA133497320	34	T>K		No	ClinGen ExAC TOPMed gnomAD
CA3619420 rs747181103	34	T>M		No	ClinGen ExAC TOPMed gnomAD
CA133497369 rs1045924845	38	F>I		No	ClinGen TOPMed gnomAD
rs868665875 CA133497399	40	W>*		No	ClinGen Ensembl
rs1396678957 CA362594592	42	G>A		No	ClinGen TOPMed
rs1175960289 CA362594595	43	A>P		No	ClinGen gnomAD
rs1052745854 CA133497408	44	T>A		No	ClinGen TOPMed
rs1335033285 CA362594610	45	P>L		No	ClinGen TOPMed
CA133497425 rs1001465794	48	R>G		No	ClinGen TOPMed
CA362594626 rs1324359451	48	R>H		No	ClinGen gnomAD
CA362594638 rs1470981028	50	L>V		No	ClinGen gnomAD
CA133497451 rs893206420	53	A>T		No	ClinGen Ensembl
rs1270615295 CA362594658	53	A>V		No	ClinGen gnomAD
CA362594660 rs773096208	54	M>L		No	ClinGen ExAC TOPMed gnomAD
CA133497487 rs899898819	54	M>T		No	ClinGen TOPMed gnomAD
CA3619425 rs773096208	54	M>V		No	ClinGen ExAC TOPMed gnomAD
CA133497491 rs998297817	55	C>F		No	ClinGen TOPMed
CA3619426 rs762488081	57	R>G		No	ClinGen ExAC TOPMed gnomAD
CA362594682 rs762488081	57	R>S		No	ClinGen ExAC TOPMed gnomAD
CA3619439 rs755001094	62	P>S		No	ClinGen ExAC gnomAD
CA3619440 rs781280523	63	V>M		No	ClinGen ExAC TOPMed gnomAD
rs374935109 CA3619441	65	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1482938531 CA362594747	65	T>I		No	ClinGen gnomAD
rs374935109 CA362594745	65	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1300474129 CA362594754	66	S>F		No	ClinGen TOPMed
CA133510188 rs537732543	67	L>F		No	ClinGen gnomAD
CA362594756 rs537732543	67	L>V		No	ClinGen gnomAD
CA362594762 rs1181958023	68	L>F		No	ClinGen gnomAD
rs1424461688 CA362594789	72	S>Y		No	ClinGen gnomAD
CA362594792 COSM1222384 rs1442459703	73	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1406803988 CA362594803	74	T>M		No	ClinGen TOPMed
CA362594817 rs1162485837	76	S>F		No	ClinGen TOPMed
CA133510213 rs1013066403	77	T>A		No	ClinGen TOPMed
rs1461313121 CA362594837	80	A>S		No	ClinGen gnomAD
rs1044985944 CA133510223	81	Q>*		No	ClinGen TOPMed gnomAD
rs749170153 CA3619444	82	R>C		No	ClinGen ExAC gnomAD
COSM1154659 CA133510245 rs927728969	82	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1448738103 CA362594852	83	L>V		No	ClinGen TOPMed
rs1229876929 CA362595277	85	R>G		No	ClinGen gnomAD
rs1334081781 CA362595295	87	T>A		No	ClinGen gnomAD
CA133514298 rs928060438	90	Q>H		No	ClinGen TOPMed
rs1448282761 CA362595326	90	Q>L		No	ClinGen TOPMed gnomAD
CA362595369 rs1269443606	95	Y>C		No	ClinGen gnomAD
rs1195799399 CA362595366	95	Y>H		No	ClinGen TOPMed
CA362595393 rs1258864242	98	Q>E		No	ClinGen gnomAD
CA362595399 rs1359606882	98	Q>H		No	ClinGen gnomAD
rs1252541056 CA362595396	98	Q>R		No	ClinGen TOPMed
rs935332143 CA133514303	99	N>Y		No	ClinGen TOPMed
rs1007008919 CA133514306	100	T>I		No	ClinGen Ensembl
rs776042978 CA3619487	101	D>E		No	ClinGen ExAC gnomAD
rs1038905007 CA133514308	102	S>G		No	ClinGen Ensembl
COSM1222380 CA362595450 rs1258651768	105	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1052833229 CA133514323	108	V>A		No	ClinGen TOPMed gnomAD
CA133514333 rs994798668	110	N>D		No	ClinGen Ensembl
CA133514347 rs759793970	112	I>V		No	ClinGen Ensembl
CA362595556 rs1443274692	118	A>V		No	ClinGen gnomAD
rs1011073565 CA133514353	121	E>K		No	ClinGen TOPMed gnomAD
CA362595599 rs1187423740	124	F>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1300750796 CA362595601	124	F>Y		No	ClinGen TOPMed

No associated diseases with Q5JS54

No regional properties for Q5JS54

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5JS54

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

1 GO annotations of molecular function

Name	Definition
protein-containing complex binding	Binding to a macromolecular complex.

1 GO annotations of biological process

Name	Definition
proteasome assembly	The aggregation, arrangement and bonding together of a mature, active proteasome complex.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P0C7N9	Psmg4	Proteasome assembly chaperone 4	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEGLVVAAGG	DVSLHNFSAR	LWEQLVHFHV	MRLTDSLFLW	VGATPHLRNL	AVAMCSRYDS
70	80	90	100	110	120
IPVSTSLLGD	TSDTTSTGLA	QRLARKTNKQ	VFVSYNLQNT	DSNFALLVEN	RIKEEMEAFP

EKF