Q5JJC8

PR
Gene name
srp54
Protein name
Signal recognition particle 54 kDa protein
Names
SRP54
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1486
EC number
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

316-448 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JJC8

Entry ID Method Resolution Chain Position Source
AF-Q5JJC8-F1 Predicted AlphaFoldDB

No variants for Q5JJC8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JJC8

No associated diseases with Q5JJC8

1 regional properties for Q5JJC8

Type Name Position InterPro Accession
domain Peptidase M14, carboxypeptidase A 217 - 528 IPR000834

Functions

Description
EC Number 3.6.5.4 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • The SRP-RNC complex is targeted to the cytoplasmic membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes.

3 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALEKLGQAL NSALKKLARS STVDEATIKE IVRDIQRALL QADVNVKLVL QLTKQIQKRA
70 80 90 100 110 120
LEEEPPAGVS KKEHIIKIVY EELTKFLGTE AKPLEIKHKP TVILTVGIQG SGKTTSVAKL
130 140 150 160 170 180
ARYLQKRGYK VGVVCSDTWR PGAYYQLRQL LDPFGIEVFG DPEEKDAVKL AREGVEHFRE
190 200 210 220 230 240
KGVDVIIVDS AGRHKEEKGL IEEMRQISEA IKPHEVILVI DGTIGQQAYN QAMAFKEATP
250 260 270 280 290 300
IGSIIVTKLD GSAKGGGALS AVAATGAPIK FIGTGERIDD LEPFDPKRFV SRLLGLGDIQ
310 320 330 340 350 360
GLLEKIEELQ KEQEFREEDM EKFLRGKFNL KDMYAQLEAM QKMGPLKQIL QMIPGLGYSL
370 380 390 400 410 420
PEDAVRVGEE KLKRYKVIMD SMTEEELENP EIINYSRIKR IARGSGATTA EVRELLNQYN
430 440
QMKKMFKSLN KRKLAKMAKK FNFGGLGI