Q5JJ64

PR
Gene name
TK1782
Protein name
Uncharacterized serpin-like protein TK1782
Names
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1782
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JJ64

Entry ID Method Resolution Chain Position Source
AF-Q5JJ64-F1 Predicted AlphaFoldDB

No variants for Q5JJ64

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JJ64

1 associated diseases with Q5JJ64

[MIM: 616814]: Preimplantation embryonic lethality 1 (PREMBL1)

A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive. {ECO:0000269|PubMed:26537248, ECO:0000269|PubMed:31897846, ECO:0000269|PubMed:33020905}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • A rare cause of female primary infertility. In affected women, ovulation proceeds normally and the retrieved oocytes appear normal, but zygote formation and division are severely impaired. Inheritance is autosomal recessive. {ECO:0000269|PubMed:26537248, ECO:0000269|PubMed:31897846, ECO:0000269|PubMed:33020905}. Note=The disease is caused by variants affecting the gene represented in this entry.

6 regional properties for Q5JJ64

Type Name Position InterPro Accession
repeat WD40 repeat 276 - 313 IPR001680-1
repeat WD40 repeat 326 - 363 IPR001680-2
repeat WD40 repeat 368 - 407 IPR001680-3
repeat WD40 repeat 410 - 447 IPR001680-4
repeat WD40 repeat 490 - 529 IPR001680-5
repeat WD40 repeat 532 - 569 IPR001680-6

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRTVLLVTV LLVFIGGCLG QMENPRPTNN PSTSHPSDSY STLPTTKYDV LKEGQEKPVV
70 80 90 100 110 120
NAINSFTFDL YKELAGNNNN VFFSPFSIET ALAMAYEGAR GKTAEEMKRV LHLPEDDDAR
130 140 150 160 170 180
WTGFRYLLLS LKSPEGSPFI LRSVNALWVQ RGYSLREEYL GIVKEFYLGE AKEVDFQGNP
190 200 210 220 230 240
AEAAREINEW VEEQTNGRIK DIVSGLSPLT RLVITNAVYF KANWSSRFRA SDTRNETFHA
250 260 270 280 290 300
PNGTVIVPMM HQTGEFPYFE NDDLQALELP YEGERLGMLI ILPKEGKFEK VEGNLSAGSI
310 320 330 340 350 360
ENILKNMREE KVKVALPKFR FEASYKLRDV LMDMGMKRAF LVPDFSGISN GENLAIEDVV
370 380 390 400 410 420
HKSFISVAEN GTEAAAATAV TLTMNAPMQE KEPKIFKADH PFIFFIYDRE TGTILFMGRM
MNPKDG