Q5JIE6
Gene name |
purA |
Protein name |
Adenylosuccinate synthetase |
Names |
AMPSase, AdSS, IMP--aspartate ligase |
Species |
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
KEGG Pathway |
tko:TK1002 |
EC number |
6.3.4.4: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5JIE6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5JIE6-F1 | Predicted | AlphaFoldDB |
No variants for Q5JIE6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5JIE6 | |||||
No associated diseases with Q5JIE6
1 regional properties for Q5JIE6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Adenylosuccinate synthase, GTP-binding site | 10 - 17 | IPR018220 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.4 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenylosuccinate synthase activity | Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' AMP biosynthetic process | The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). |
| IMP metabolic process | The chemical reactions and pathways involving IMP, inosine monophosphate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSYIVVGGQ | WGDEGKGSVI | AYLALKDEPE | VIARGGVGTN | AGHSVFINGK | KYAVRQLPTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FMQTKARLLV | GAGVLVDPEV | FFHELEHLKD | FNVRGRVGID | YRCAIIEEKH | KQLDRSNHHL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HEEIGTTGSG | CGPANADRVM | RRAKLAKDIK | ELEPYLTDVA | AEVNDALDDG | KLVLIEGTQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FGLSLYYGTY | PYVTSKDTTA | SAIASDVGIG | PTRVDDVIVV | FKSFPTRVGA | GPFPTEMPQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAERLGLVEY | GTVTGRRRRV | GWFDFEFARY | SARINGATML | ALTMLDKYDG | EAFGVTDYDK |
| 310 | 320 | 330 | |||
| LPKRAKEFVE | EIEERVGVPV | GLIKTGPELE | HVIDRRENI |