Q5JHM9

PR
Gene name
pyrB
Protein name
Aspartate carbamoyltransferase
Names
Aspartate transcarbamylase, ATCase
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK2196
EC number
2.1.3.2: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JHM9

Entry ID Method Resolution Chain Position Source
AF-Q5JHM9-F1 Predicted AlphaFoldDB

No variants for Q5JHM9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JHM9

No associated diseases with Q5JHM9

2 regional properties for Q5JHM9

Type Name Position InterPro Accession
domain Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain 154 - 303 IPR006131
domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding 6 - 147 IPR006132

Functions

Description
EC Number 2.1.3.2 Carboxy- and carbamoyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aspartate carbamoyltransferase activity Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.

4 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDWKGRDVIS IRDFSKEDIE FVLKVAERLE EELNEKGSLD YARGKILATL FFEPSTRTRL
70 80 90 100 110 120
SFESAMHRLG GSVIGFSSAS STSVKKGESL ADTIKTVEQY SDVIVIRHPM EGAARLAAEV
130 140 150 160 170 180
AGIPVINAGD GSNQHPTQTL LDLYTIKKAF GKIDGLTIGL LGDLKYGRTV HSLAEALAFY
190 200 210 220 230 240
DVELYLISPE LLRMPKHIVD ELRERGVKVY ETTDLEGAIP KLDVLYVTRI QRERFPDEEE
250 260 270 280 290 300
YLKVKGSYQV NLEVLKNAKE TLKVMHPLPR VDEIHPEVDK TKHALYFRQV FSGVPVRMAL
LGLTLGVLGV