Q5JH16

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1408
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JH16

Entry ID Method Resolution Chain Position Source
AF-Q5JH16-F1 Predicted AlphaFoldDB

No variants for Q5JH16

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JH16

No associated diseases with Q5JH16

2 regional properties for Q5JH16

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 100 - 407 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 410 - 559 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

2 GO annotations of biological process

Name Definition
amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEIRELVLK YALINAYTHR GKANPKAVIG KVLGENPELR KRAKEIIPLV NEVVNEVNSL
70 80 90 100 110 120
SLEEQEAKLR EIYPEFFEEK NEKKEEKKGL PPLPKAERGK VVTRFAPNPD GAFHLGNARA
130 140 150 160 170 180
AILSHEYARM YDGKFILRFD DTDPKVKRPE PIFYEWIKED LEWLGFRIDE IHIASDRLEI
190 200 210 220 230 240
YYDYAEKLIK MGKAYVCTCP PEKFRELRDK GIACPHREEP VEVQLERWRK MLNGEYREGE
250 260 270 280 290 300
AVVRIKTDLN HPNPAVRDWP ALRIIDNPNH PRTGNKYRVW PLYNFASAID DHELGVTHIF
310 320 330 340 350 360
RGQEHAENET RQRYVYEYFG WEYPVTVHHG RLSIEGVILS KSKTRKGIEE GKYLGWDDPR
370 380 390 400 410 420
LGTIRALRRR GIKPEAIREL IIEVGLKRSD TTISWDNLAA INRKIIEPIA NRYFFVADPI
430 440 450 460 470 480
PMYVEGAQEF TAEIPLHPDY PERGVRRLKF EPDKPVYVSK DDMELFKPGN FVRLKDLFNV
490 500 510 520 530 540
EIMEVNENGI RARFHSFEYE VARENRWRMV HWVTEGKACE VWVPEGDELI IREGLLESDA
550 560 570
DVKVDDIVQF ERFGFVRIDD VRPEKVVAIF AHK