Q5JGV6

PR
Gene name
hel308
Protein name
ATP-dependent DNA helicase Hel308
Names
ATP-dependent Holliday junction unwindase Hjm
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1332
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

409-479 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JGV6

Entry ID Method Resolution Chain Position Source
AF-Q5JGV6-F1 Predicted AlphaFoldDB

No variants for Q5JGV6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JGV6

No associated diseases with Q5JGV6

13 regional properties for Q5JGV6

Type Name Position InterPro Accession
domain Helix-hairpin-helix DNA-binding motif, class 1 1048 - 1067 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 1081 - 1100 IPR003583-2
domain Hint domain C-terminal 695 - 740 IPR003586
domain Intein DOD homing endonuclease 500 - 640 IPR004042
domain Homing endonuclease, LAGLIDADG 591 - 678 IPR004860
ptm Intein N-terminal splicing region 332 - 400 IPR006141
domain Intein 497 - 509 IPR006142-1
domain Intein 595 - 607 IPR006142-2
domain Intein 627 - 642 IPR006142-3
domain Intein 712 - 729 IPR006142-4
domain DEAD/DEAH box helicase domain 26 - 180 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 20 - 204 IPR014001
domain Intein C-terminal splicing region 714 - 735 IPR030934

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

3 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVDELPIDE RIKRVIKERG IEELYPPQAE ALKSGVLEGK NLVLAIPTAS GKTLVSEIVM
70 80 90 100 110 120
VNKLLSEGGK AVYLVPLKAL AEEKYREFKE WEVLGLRVAA TTGDYDSTDE WLGRYDIIVA
130 140 150 160 170 180
TAEKFDSLLR HGASWIKDVK LVVADEVHLI GSYDRGATLE MILTHMLGKA QILALSATVG
190 200 210 220 230 240
NAEELAEWLD ASLVVSDWRP VELRKGVFHL GQLFWEDGKI DHYPENWESL VLDAVKKGKQ
250 260 270 280 290 300
ALVFVNTRRS AEKEAISLSS KVSKLLTKPE TRRLEELISS IEDNPTTEKL KRALKGGVAF
310 320 330 340 350 360
HHAGLSRAER TLIEDAFRNG LIKVITATPT LCMHPDTYVV TKSGAKKVSE LTEGDEVLTH
370 380 390 400 410 420
TGTFKKVIQP LRREHKGRLL VIKAYGTVPV KITPEHMVWV VKQIRHKSHY SDGRQVIWWE
430 440 450 460 470 480
FEGPEWMTAQ ELKERLESET DPKVSYMLLQ PIPEPSVDAD KIPLRKEVYV VNQHGKTDKL
490 500 510 520 530 540
HPSVKRTPEY LPLNFETARL IGLWIAEGST SKNGVIKFDI SSNEEDLTEF ITGTIRKYFP
550 560 570 580 590 600
HAKIVVKDHE RNRRTVRFCN KRFAEWLREN IGHGADNKSI PPLLLLNKNR EVRLGLLRGL
610 620 630 640 650 660
IEGDGYVRRE SQRRANYISY STVSPSLAYQ LQLLVASLGY TSSIHRSIRT EGIGKTRKPI
670 680 690 700 710 720
YDVKVSGKSY YSLLEELGFE VPQRGNRTYN VNRTWKNYLL LKVRSIEEEE YEGDVYNLEV
730 740 750 760 770 780
EGDESYSVGF IVHNSAGINL PAFRVIIRDT KRYANFGWTD IPVLEIQQMM GRAGRPKYDK
790 800 810 820 830 840
VGEAIIVART EDPKKLIDRY IHGKPEKLFS MLANEQAFRS QVLALITNFG VEDFRELVDF
850 860 870 880 890 900
LSRTFYAHQR GDTSSLEYKA KDIVYFLIEN EFIDMDVENR FIALPFGRRT SQLYIDPLTA
910 920 930 940 950 960
KKFKDAFPAI ERNPNPFGIF QLLASTPDMA TLTARRREME DYLDLAYEME EHLYSSIPYY
970 980 990 1000 1010 1020
EDSRFQGFLG QVKTAKVLLD WINEVPEARI YETYNIDPGD LYRILELADW LMYSLIELYK
1030 1040 1050 1060 1070 1080
LFEPKEDVLQ YLRDLHLRLR HGVREELLEL VKLPNIGRRR ARALYNAGFR SVEDILRAKP
1090 1100 1110 1120
KDLLQVEGIG LKIIEGIYRH LGVEYTISEK EKPKKRKGNL YDFLK