Q5JGR9
Gene name |
infB (TK1305) |
Protein name |
Probable translation initiation factor IF-2 |
Names |
|
Species |
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) |
KEGG Pathway |
tko:TK1305 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5JGR9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5JGR9-F1 | Predicted | AlphaFoldDB |
No variants for Q5JGR9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5JGR9 | |||||
No associated diseases with Q5JGR9
16 regional properties for Q5JGR9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translational (tr)-type GTP-binding domain | 551 - 768 | IPR000795 |
| domain | Hint domain C-terminal | 527 - 572 | IPR003586 |
| domain | Hint domain N-terminal | 19 - 131 | IPR003587 |
| domain | Intein DOD homing endonuclease | 232 - 362 | IPR004042 |
| domain | Translation elongation factor EFTu-like, domain 2 | 794 - 872 | IPR004161 |
| domain | Homing endonuclease, LAGLIDADG | 319 - 390 | IPR004860 |
| domain | Small GTP-binding protein domain | 567 - 701 | IPR005225 |
| ptm | Intein N-terminal splicing region | 21 - 111 | IPR006141 |
| domain | Intein | 98 - 111 | IPR006142-1 |
| domain | Intein | 229 - 241 | IPR006142-2 |
| domain | Intein | 321 - 333 | IPR006142-3 |
| domain | Intein | 349 - 364 | IPR006142-4 |
| domain | Intein | 544 - 561 | IPR006142-5 |
| domain | Translation initiation factor IF- 2, domain 3 | 879 - 993 | IPR023115 |
| domain | Elongation factor Tu-type domain | 1014 - 1100 | IPR029459 |
| domain | Intein C-terminal splicing region | 546 - 567 | IPR030934 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intein-mediated protein splicing | The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. |
| intron homing | Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKRIRQPII | AVLGHVDHGK | CLLPDEKVIL | PEHGPITLKG | LFDLAKETVV | ADNEKEIRKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAKLTIVGED | GRLRVLESPY | VWKVRHRGKM | LRVKLKNWHS | VSVTPEHPFL | TTRGWVRADQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKPGDYVAVP | RVIHGNESDE | RFVSFVYEKL | KNDELIAKLR | GEVLSKISSE | FKGDRAYKVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNVFRWEDIE | RLNLWDEVER | VAFTPRMHRS | GKPLHYVKLP | RSPEEWEAFF | YFAGVMFGDG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQDKIANNDV | EVYEELKKLS | VLGVAVKRVE | RTTSYEIELT | NGKNALLRLL | RVLFEYPERQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAKSIRVPRI | LFIAPRKYVS | RFLRGYFDAD | GHVSLKDARI | EVTSASQEFL | EDLSLLLLRF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GIVSKIYRSD | YTTLVISGRR | NLDLFRRYIG | FSVKNKAEAL | EKAIKKSRRS | ESYPIFEELK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RLRLLFGFTR | TELNSNVPFY | GKYESEEAPS | YETLMRILDA | IEKGSINLDK | KIAVLEGRIR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DHNYIKAFEK | DGLIKDGKLT | ELGRELLEVW | RNREFDSSDV | DYIRNLAENL | VFIPVEDIEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FEYEGYVYDV | TTETHNFVAN | GILVHNTTLL | DRIRHTNVAG | KEAGGITQHI | GATEVPIDVV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KQLAGPLIKL | WKGEIKLPGL | LFIDTPGHEA | FTSLRARGGS | LADLAVLVVD | INEGFQPQTI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ESIEILRRYR | TPFIVAANKI | DRIKGWVIEE | DEPFLVNIKK | QDQRAIQELE | TKLWELIGKF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YEMGFNANRF | DRVQDFTREL | AIVPISAKYG | IGIPELLVLI | AGLSQKYLEE | KLKIEVEGPA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RGTILEVREE | VGLGTTIDVI | IYDGTLRKDD | TIVVGGKDKA | IVTKIRALLK | PKPLDEIRDP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RFRFDQVDEV | TAAAGVKIAA | PGLEEALAGS | PVIAARSEEE | IEKAKQEILS | QIQSVVINTG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KIGVIVKADT | LGSLEALSKE | LQEKGIPIRK | ADVGNISKTD | VMEALSVKEE | EPKYGVVLGF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NVKVNEDAEE | VANAKGVPIF | VGNIIYKLIE | DYEAWVKEEE | EKRKRELLKN | VTFPGVIRLY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| PDERYVFRRS | KPAIVGVEVL | EGRIRPGVTL | IKETGEKVGV | IKSIKNKNDF | VQEAKKGDAV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AIAIEGAIVG | RHIHPGETLY | VDLSKNDVII | LAKQLKDELE | ETDIKALKMT | AKVKAKEDPF |
| WRAV |