Q5JE63

PR
Gene name
pfdA2
Protein name
Prefoldin subunit alpha 2
Names
GimC subunit alpha 2
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1121
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JE63

Entry ID Method Resolution Chain Position Source
AF-Q5JE63-F1 Predicted AlphaFoldDB

No variants for Q5JE63

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JE63

No associated diseases with Q5JE63

No regional properties for Q5JE63

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5JE63

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
prefoldin complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.

1 GO annotations of molecular function

Name Definition
unfolded protein binding Binding to an unfolded protein.

2 GO annotations of biological process

Name Definition
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEEKKTRTL EQIQDEIRSY LGEIEYLRSQ VGVIDATITD LRTVDATLAY LKEKGKGKEI
70 80 90 100 110 120
YIPLGSGVAI RGKIENPDDV IMDVGAGILV GATVDEAREN IEKRIKALMD LRLALLRKIE
130 140
EDTRKVNELL KELQEMQPEK RE