Q5JDS2

PR
Gene name
atpI (TK1597)
Protein name
V-type ATP synthase subunit I
Names
V-ATPase subunit I
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK1597
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JDS2

Entry ID Method Resolution Chain Position Source
AF-Q5JDS2-F1 Predicted AlphaFoldDB

No variants for Q5JDS2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JDS2

No associated diseases with Q5JDS2

No regional properties for Q5JDS2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5JDS2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

2 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

1 GO annotations of biological process

Name Definition
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFRPEEMVKL EVITLNRYKD TLLTYLHEAG AVEVREVKVE LAQKDTPNEY HRKAASYSIS
70 80 90 100 110 120
MSRLVEFLGT YRKAAGGGIK EFFFPKEKPK RTYRYERLEK LIKDVEEFLG KVEPEIKAIE
130 140 150 160 170 180
GRMNSLSTEI ERIKEQIGIL DILTPLNIDV SYLRHCGVVE VTVGLVDRTR VKELADALKK
190 200 210 220 230 240
ETENHVAIIT KEASDKALVV IVNLARDHDK VNTLLAKFSV EKLEIPEGEG TPKELMKEYS
250 260 270 280 290 300
KKLAEKEKEL EEAKKEASKL AEKYYDDVLF YKELVDNERD KSTVLPMLAR TNMTFALTGW
310 320 330 340 350 360
VPRPDVQKIL EGIKRITEGK AYINVREPRK EELEEMPVKL KNPGWARPFE MLTEMYGVPR
370 380 390 400 410 420
HDEIDPTPII AFTYSFFFGF MLTDFLYGLI VGIVAALLVK GHKKFNDGTY KFAYILLWSA
430 440 450 460 470 480
FFTMLLGALF GSYFGNAADI MLQYITGDQN AHAWRLLDPL REPMPMLLAA LAIGLAHLFL
490 500 510 520 530 540
GYTLGFVIKW KNGDRKGAVF EQLPWMIIII GVALLASQRE GLDAAAKAIL GTGIALFAVG
550 560 570 580 590 600
ELVINGGLAA LMIISDFFGF VGNWLSYARL MALALATGGI AMVINVLVGM VWAIKFLYIG
610 620 630 640 650 660
PIIGLIIFFG GQLFSTAINA LGAFVHALRL HYVEFFGTFY SGEGKRFEPF KSKREVSKLE
LEV