Q5JDB6

PR
Gene name
truD
Protein name
Probable tRNA pseudouridine synthase D
Names
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D
Species
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
KEGG Pathway
tko:TK2302
EC number
5.4.99.27: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

318-398 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5JDB6

Entry ID Method Resolution Chain Position Source
AF-Q5JDB6-F1 Predicted AlphaFoldDB

No variants for Q5JDB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5JDB6

No associated diseases with Q5JDB6

2 regional properties for Q5JDB6

Type Name Position InterPro Accession
domain Pseudouridine synthase, TruD, insertion domain 154 - 302 IPR011760
conserved_site Pseudouridine synthase TruD, conserved site 76 - 89 IPR020119

Functions

Description
EC Number 5.4.99.27 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

2 GO annotations of biological process

Name Definition
pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYREFFSQF KHLSEKPGIG GKIKIYPEDF IVIEEPIPSI FEGRKYAIFL LKKRNWETMA
70 80 90 100 110 120
AVKEIAKRAG INYREIGFAG TKDRHAVTYQ YISVPAEARE RVEQVSIRDI ELRFVSYGRF
130 140 150 160 170 180
IKLGHLLGNR FRIIVRDVSE DAFDRTKEIV RELREKGGFP NYFGYQRFGE RRVVNHIIGK
190 200 210 220 230 240
LLLQGDFEGA ARLFLGAHDG SMEGDEARKN FWETGDVERA LEEFPGFLRY ERTLLHRYKD
250 260 270 280 290 300
TGNWKRAFLS LPLPIMRIFI HAYQSYLFNL YLSRRIEEGL PLNEPLVGDI VVQVKGGIPY
310 320 330 340 350 360
RDRTYRVTET NLEFVREKVR KNQAMVSGPL FGFAMRRAKG LPGELEKEIL EEEGLSLETF
370 380 390 400 410
RRLPKPMAEP GGRRELLLRP MGMAYGYIQE EGMCFRFFLP KGTYATSVLR EIMKDH