Q5I6M2
Gene name |
HOG1 (STK1) |
Protein name |
Mitogen-activated protein kinase HOG1 |
Names |
MAP kinase HOG1, MAP kinase STK1 |
Species |
Setosphaeria turcica (Northern leaf blight fungus) (Exserohilum turcicum) |
KEGG Pathway |
|
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5I6M2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5I6M2-F1 | Predicted | AlphaFoldDB |
No variants for Q5I6M2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5I6M2 | |||||
No associated diseases with Q5I6M2
4 regional properties for Q5I6M2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 23 - 305 | IPR000719 |
| conserved_site | Mitogen-activated protein (MAP) kinase, conserved site | 58 - 156 | IPR003527 |
| active_site | Serine/threonine-protein kinase, active site | 140 - 152 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 29 - 53 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAFGLVCSA | KDQLTNQAVA | VKKIMKPFST | PVLSKRTYRE | LKLLKHLRHE | NIISLSDIFI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SPLEDIYFVT | ELLGTDLHRL | LTSRPLEKQF | IQYFLYQILR | GLKYIHSAGV | VHRDLKPSNI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVNENCDLKI | CDFGLARIQD | PQVTGYVSTR | YYRAPEIMLT | WQKYDVEVDI | WSAGCIFAEM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEGKPLFPGK | DHVNQFSIIT | ELLGTPPDDV | IQTICSENTL | RFVQPLPKRE | RQPLANKFKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEPEAVDLLE | NMLVFDPRKR | VRAEQALAHP | YLAPYHDPTD | EPIAEEKFDW | SFNDADLPVD |
| 310 | 320 | ||||
| TWKIMMYSEI | LDYHNVDAAA | QDAPESNGS |