Q5HZM6

PR
Gene name
elp3
Protein name
Elongator complex protein 3
Names
tRNA uridine(34) acetyltransferase
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:496354
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HZM6

Entry ID Method Resolution Chain Position Source
AF-Q5HZM6-F1 Predicted AlphaFoldDB

No variants for Q5HZM6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HZM6

No associated diseases with Q5HZM6

No regional properties for Q5HZM6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5HZM6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
phosphorylase kinase regulator activity Modulation of the activity of the enzyme phosphorylase kinase.
tRNA binding Binding to a transfer RNA.
tRNA uridine(34) acetyltransferase activity Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine.

5 GO annotations of biological process

Name Definition
negative regulation of protein ubiquitination Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
neural crest cell migration The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKPDRGMRGN MSQAELMMMT VADVIKQLVE AHEQGKDVNL NKLKTKTSAK YGLSAQPRLV
70 80 90 100 110 120
DIIAAVPPQY RKILVPKLKA KPIRTASGIA VVAVMCKPHR CPHINFTGNI CVYCPGGPDS
130 140 150 160 170 180
DFEYSTQSYT GYEPTSMRAI RARYDPYLQT RHRVEQLKQL GHNVDKVEFI VMGGTFMALP
190 200 210 220 230 240
EDYRDFFIRN LHDALSGHTS NSVSEAVRYS ERSNTKCVGI TIETRPDYCL KRHLSDMLCY
250 260 270 280 290 300
GCTRLEIGVQ SVYEDVARDT NRGHTVKAVC ESFHLSKDAG FKVVSHMMPD LPNMGLERDI
310 320 330 340 350 360
EQFIEFFENP AFRPDGMKLY PTLVIRGTGL YELWKTGRYR SYSPSTLVDL VARILALVPP
370 380 390 400 410 420
WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTEC RDVRTREVGI QEIHHKVRPY
430 440 450 460 470 480
QVELIRRDYV ANGGWETFLS YEDPEQDILI GLLRLRKCSE ESFRPELKGG VSIVRELHVY
490 500 510 520 530 540
GSVVPISSRD PSKFQHQGFG MLLMEEAERI ARDEHGSWKI AVISGVGTRN YYRKIGYELE
GPYMVKRLD